Neural effect of childhood maltreatment on neurovascular coupling in adolescent depression.
Childhood maltreatment (CM) is a pivotal risk factor for depression, yet its potential contribution to major depressive disorder (MDD) in adolescents requires further investigation. This study aims to scrutinize the specific impact of CM on neurovascular coupling (NVC) in adolescents with MDD. A coh...
| Published in: | European Child & Adolescent Psychiatry Vol. 34; no. 9; pp. 2859 - 2871 |
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| Main Authors: | , , , , , , , , |
| Format: | diagnostic images pictorial research tables/charts Journal Article |
| Published: |
Springer Nature
Sep2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188516209&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188516209 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Sep2025 vid: 34 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 188516209 184215878 188516209 188516209 10.1007/s00787-025-02708-7 188516209 ppf: 2859 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Neural effect of childhood maltreatment on neurovascular coupling in adolescent depression. aug: au: Liu, Sangni Fan, Dandan He, Cancan Liu, Xinyi Zhang, Haisan Zhang, Hongxing Zhang, Zhijun Xie, Chunming Pan, PingLei affil: https://ror.org/04ct4d772 Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, 210009, Nanjing, Jiangsu, China sug: subj: Child Abuse Complications Adverse Childhood Experiences Psychosocial Factors Depression Psychosocial Factors Cerebrovascular Circulation Physiology Magnetic Resonance Imaging Methods Human Male Female Adolescence Prospective Studies Functional Connectivity Reward Machine Learning Prefrontal Cortex Physiopathology Thalamus Physiopathology Temporal Lobe Physiopathology Cross Sectional Studies China Scales Correlational Studies Correlation Coefficient Two-Way Analysis of Variance Post Hoc Analysis Logistic Regression T-Tests Multiple Regression Sensitivity and Specificity Funding Source Questionnaires Adolescent: 13-18 years Male Female ab: Childhood maltreatment (CM) is a pivotal risk factor for depression, yet its potential contribution to major depressive disorder (MDD) in adolescents requires further investigation. This study aims to scrutinize the specific impact of CM on neurovascular coupling (NVC) in adolescents with MDD. A cohort of 189 adolescents, comprising 54 MDD with CM, 45 MDD without CM, 33 healthy controls (HC) with CM, and 57 HC without CM, underwent multimodal MRI scans. Cerebral blood flow (CBF) was computed to evaluate vascular responses, while functional connectivity strength (FCS) and amplitude of low-frequency fluctuation (ALFF) were measured to assess neuronal activity. NVC was calculated using whole gray matter CBF-neuronal activity correlation coefficients and regional CBF/neuronal activity ratios. MDD×CM interactions on NVC, CBF, and neuronal activity were analyzed, with further exploration of the associations between these abnormal NVC ratios and CM experience. Support vector machine classifiers were employed to differentiate MDD adolescents. Results revealed a significant MDD×CM interactive effect on CBF-FCS coefficients at whole gray matter level. Regionally, these interactions on NVC ratios primarily occurred in the reward systems, including bilateral anterior cingulate/orbitofrontal cortex, thalamus/mesial temporal lobe, and left occipitotemporal lobe, correlating with CM measurements. Notably, the integration of NVC ratio, CBF, and neuronal activity yielded robust classification performance in distinguishing MDD adolescents. These findings reinforce the importance of reward system for MDD adolescents related to CM, proposing a novel neuroimaging biomarker for early recognition of adolescent depression. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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