The possible effect of inflammation on non-suicidal self-injury in adolescents with depression: a mediator of connectivity within corticostriatal reward circuitry.
Non-suicidal self-injury (NSSI) in adolescent depression is a prevalent and clinically significant behavior linked to dysregulated peripheral inflammation and corticostriatal circuitry dysfunction. However, the neuroimmune mechanisms bridging these systems remain poorly understood. Here, we combined...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 9; pp. 2871 - 2886 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188516210&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188516210 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Sep2025 vid: 34 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 188516210 184225000 188516210 188516210 10.1007/s00787-025-02709-6 188516210 ppf: 2871 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The possible effect of inflammation on non-suicidal self-injury in adolescents with depression: a mediator of connectivity within corticostriatal reward circuitry. aug: au: Qiao, Dan Qi, Yirun Zhang, Xiaoyu Wen, Yujiao Huang, Yangxi Li, Yiran Liu, Penghong Li, Gaizhi Liu, Zhifen affil: https://ror.org/02vzqaq35 Department of Psychiatry, First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, 030001, Taiyuan, China sug: subj: Self-Injurious Behavior Risk Factors Inflammation Depression Complications Functional Connectivity Neuroradiography Reward Antiinflammatory Agents Cytokines Human Funding Source Male Female Adolescence Child Young Adult Cross Sectional Studies China Antidepressive Agents Psychotherapy Nervous System Diseases Mental Disorders Magnetic Resonance Imaging Enzyme-Linked Immunosorbent Assay Interleukins Analysis of Covariance Pearson's Correlation Coefficient Fisher's Exact Test Descriptive Statistics Post Hoc Analysis Data Analysis Software Confidence Intervals Scales Adolescent: 13-18 years Child: 6-12 years Male Female ab: Non-suicidal self-injury (NSSI) in adolescent depression is a prevalent and clinically significant behavior linked to dysregulated peripheral inflammation and corticostriatal circuitry dysfunction. However, the neuroimmune mechanisms bridging these systems remain poorly understood. Here, we combined peripheral cytokine profiling with static/dynamic functional connectivity (sFC/dFC) analysis to investigate the potential influence of inflammaton on corticostriatal circuit related to NSSI. A set of peripheral blood inflammatory markers and resting-state functional magnetic resonance imaging (rs-fMRI) were collected in depression with NSSI (NSSI+), depression without NSSI (NSSI-), and healthy controls (HC). We first ascertain group differences in level of pro- and anti-inflammatory cytokines. And using ventral/dorsal striatal seeds, we compared whole-brain, voxel-wise sFC and dFC differences across three groups. Further, we tested the mediation effects of connectivity in the association between inflammatory markers and NSSI frequency. NSSI+ group exhibited elevated pro-inflammatory cytokines (C-reactive protein (CRP), interleukin (IL)-1, and IL-6) whereas reduced anti-inflammatory cytokines (IL-10), compared to NSSI− and HC. Neuroimaging analysis revealed corticostriatal dysconnectivity mainly characterized by static hyperconnectivity between dorsal striatum and thalamus, dynamic instability in dorsal striatum-lingual pathways, and dynamic rigidity in ventral striatum-prefrontal/temporal/occipital gyrus circuits. Critically, sFC of dorsal striatum-thalamus and dFC of dorsal striatum-lingual gyrus mediated the prospective association between altered CRP and NSSI frequency, establishing corticostriatal circuits as conduits for inflammatory effects on NSSI. By bridging molecular psychiatry with circuit neuroscience, this work advances precision management of NSSI in adolescent depression, prioritizing biomarker-driven strategies to disrupt neuroimmune maladaptation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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