Improving Prediction of Amyloid Deposition in Mild Cognitive Impairment With a Timed Motor Task.
Cortical amyloid deposition is one of the hallmark biomarkers of Alzheimer's disease (AD). However, given how cost- and time-intensive amyloid imaging can be, there is a continued need for a low-cost, non-invasive, and accessible enrichment strategy to pre-screen individuals for their likelihood of...
| Publicado en: | American Journal of Alzheimer's Disease & Other Dementias Vol. 37; pp. 1 - 8 |
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| Autores principales: | , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
2/24/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188519807&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188519807 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15333175 RUQ jtl: American Journal of Alzheimer's Disease & Other Dementias issn: 15333175 maglogo: Y pubinfo: dt: 2/24/2022 vid: 37 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 188519807 188519807 188519807 10.1177/15333175211048262 188519807 ppf: 1 ppct: 7 formats: tig: atl: Improving Prediction of Amyloid Deposition in Mild Cognitive Impairment With a Timed Motor Task. aug: au: Schaefer, Sydney Y. Duff, Kevin Hooyman, Andrew Hoffman, John M. affil: School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, USA sug: subj: Mild Cognitive Impairment Pathology Motor Skills Evaluation Motor Activity Evaluation Amyloids Analysis Biological Markers Analysis Task Performance and Analysis Human Aged, 80 and Over Funding Source Mild Cognitive Impairment Symptoms Amnesia Positron-Emission Tomography Male Female Aged Neuropsychological Tests Scales Chi Square Test ROC Curve Confidence Intervals Descriptive Statistics Analysis of Variance Multiple Regression Data Analysis Software Aged, 80 & over Aged: 65+ years Male Female ab: Cortical amyloid deposition is one of the hallmark biomarkers of Alzheimer's disease (AD). However, given how cost- and time-intensive amyloid imaging can be, there is a continued need for a low-cost, non-invasive, and accessible enrichment strategy to pre-screen individuals for their likelihood of amyloid prior to imaging. Previous work supports the use of coordinated limb movement as a potential screening tool, even after controlling for cognitive and daily function. Thirty-six patients diagnosed with amnestic mild cognitive impairment over the age of 65 underwent 18F-Flutemetamol amyloid-positron emission tomography (PET) imaging and then completed a timed motor task involving upper limb coordination. This task takes ∼5 minutes to administer and score. Multivariate linear regression and receiver operator characteristic analyses showed that including motor task performance improved model prediction of amyloid burden. Results support the rationale for including functional upper extremity motor assessment as a cost- and time-effective means to screen participants for amyloid deposition. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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