Task-Evoked Pupillary Response as a Potential Biomarker of Dementia and Mild Cognitive Impairment: A Scoping Review.
Pupil dilation functions as a proxy for cognitive effort and can be measured through automated pupillometry. The aim of this scoping review is to examine how individuals with cognitive impairment differ in task-evoked pupillary responses relative to cognitively healthy individuals. A systematic lite...
| Publicado en: | American Journal of Alzheimer's Disease & Other Dementias Vol. 38; pp. 1 - 10 |
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| Autores principales: | , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
3/10/2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188519877&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188519877 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15333175 RUQ jtl: American Journal of Alzheimer's Disease & Other Dementias issn: 15333175 maglogo: Y pubinfo: dt: 3/10/2023 vid: 38 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 188519877 188519877 188519877 10.1177/15333175231160010 188519877 ppf: 1 ppct: 9 formats: tig: atl: Task-Evoked Pupillary Response as a Potential Biomarker of Dementia and Mild Cognitive Impairment: A Scoping Review. aug: au: Zeeman, Michael Figeys, Mathieu Brimmo, Tolani Burnstad, Cleo Hao, Jasmine Kim, Esther S affil: Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada sug: subj: Dementia Diagnosis Mild Cognitive Impairment Diagnosis Task Performance and Analysis Pupil Physiology Biological Markers Human Medline Embase Psycinfo CINAHL Database Scoping Review Descriptive Statistics Confidence Intervals Early Diagnosis Reflex, Pupillary Evaluation Cognition Parkinson Disease Alzheimer's Disease Checklists ab: Pupil dilation functions as a proxy for cognitive effort and can be measured through automated pupillometry. The aim of this scoping review is to examine how individuals with cognitive impairment differ in task-evoked pupillary responses relative to cognitively healthy individuals. A systematic literature search across six databases was conducted to identify studies examining changes in pupillary responses evoked by cognitive tasks comparing patients with dementia to healthy controls. Eight articles met inclusion criteria and were included for review. Differences in task-evoked pupillary response between cognitively impaired and cognitively healthy participants were observed across studies. Pupil dilation is decreased in patients with Alzheimer's Disease compared to controls, with no difference observed in patients with mild cognitive impairment. A mild, non-significant trend towards reduced pupil dilation in patients with either Parkinson's Disease or Dementia with Lewy Bodies suggests a similar but less pronounced effect than in AD patients. Further research is required to examine the utility of task-evoked pupillary responses as a potential biomarker indexing cognitive decline in individuals transitioning to mild cognitive impairment and/or dementia. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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