Guidance for Fecal Microbiota Transplantation Trials in Ulcerative Colitis: The Second ROME Consensus Conference.
Background Fecal microbiota transplantation (FMT) is emerging as a potential treatment modality for individuals living with inflammatory bowel disease (IBD). Despite its promise, the effectiveness of FMT for treating IBD, particularly for ulcerative colitis (UC), still requires thorough clinical inv...
| Published in: | Inflammatory Bowel Diseases Vol. 31; no. 9; pp. 2408 - 2420 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
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Oxford University Press / USA
Sep2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188554652&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188554652 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10780998 N0V jtl: Inflammatory Bowel Diseases issn: 10780998 maglogo: N pubinfo: dt: Sep2025 vid: 31 iid: 9 pid: 622 pub: Oxford University Press / USA artinfo: ui: 188554652 188554652 188554652 10.1093/ibd/izaf013 188554652 ppf: 2408 ppct: 12 formats: tig: atl: Guidance for Fecal Microbiota Transplantation Trials in Ulcerative Colitis: The Second ROME Consensus Conference. aug: au: Lopetuso, Loris R Deleu, Sara Puca, Pierluigi Abreu, Maria Teresa Armuzzi, Alessandro Barbara, Giovanni Caprioli, Flavio Chieng, Siew Costello, Samuel Paul Damiani, Andrea Danese, Silvio Chierico, Federica Del D'Haens, Geert Dotan, Iris Facciotti, Federica Falony, Gwen Fantini, Massimo Claudio Fiorino, Gionata Gionchetti, Paolo Godny, Lihi affil: IBD Unit, CEMAD, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy sug: subj: Fecal Microbiota Transplantation Standards Fecal Microbiota Transplantation Methods Colitis, Ulcerative Therapy Colitis, Ulcerative Microbiology Practice Guidelines Treatment Outcomes Human Funding Source Delphi Technique Clinical Trials Consensus Congresses and Conferences Feces Microbiology Microbiota Drug Effects Metabolomics Methods Transplant Donors Ecosystem Inflammatory Bowel Diseases Therapy Biological Therapy Methods Study Design Implementation Science Colonoscopy Methods Prediction Models Descriptive Statistics Bacterial Colonization Drug Resistance, Multiple ab: Background Fecal microbiota transplantation (FMT) is emerging as a potential treatment modality for individuals living with inflammatory bowel disease (IBD). Despite its promise, the effectiveness of FMT for treating IBD, particularly for ulcerative colitis (UC), still requires thorough clinical investigation. Notwithstanding differences in methodologies, current studies demonstrate its potential for inducing remission in UC patients. Therefore, standardized and robust randomized clinical trials (RCTs) are needed to further support its efficacy for managing UC. The aim of the second Rome Consensus Conference was to address gaps and uncertainties identified in previous research regarding FMT and to offer a robust framework for future studies applied to the treatment of UC. Methods Global experts in the field of clinical IBD, mucosal immunology, and microbiology (N = 48) gathered to address the need for standardized clinical trials in FMT investigation. The group focused on key issues, such as stool donation, donor selection, characterization of fecal biomass, potential administration routes, as well as the process of induction, maintenance, and endpoint readouts. Results and Conclusions The consensus achieved during this conference established standardization of methods and protocols to enhance the current quality of research, with the aim of eventual implementation of FMT in managing UC and the ultimate goal of improving patient outcomes. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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