Application of cold atmospheric plasma in pyoderma gangrenosum: a pilot study.
Objective: The application of cold atmospheric plasma (CAP) has been described as a promising therapeutic approach for wound healing. Its use in immunologically mediated wounds such as pyoderma gangrenosum (PG) has not yet been sufficiently investigated. This pilot study aimed to evaluate the effica...
| Publicado en: | Journal of Wound Care Vol. 34; no. 10; pp. 882 - 891 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Mark Allen Holdings Limited
Oct2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188602280&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188602280 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09690700 H3U jtl: Journal of Wound Care issn: 09690700 maglogo: N pubinfo: dt: Oct2025 vid: 34 iid: 10 pid: 11383 pub: Mark Allen Holdings Limited artinfo: ui: 188602280 188602280 188602280 10.12968/jowc.2024.0018 188602280 ppf: 882 ppct: 9 formats: tig: atl: Application of cold atmospheric plasma in pyoderma gangrenosum: a pilot study. aug: au: Gewiss, Caroline Gehrdau, Kathrin Hischke, Sandra Zirkenbach, Franziska Augustin, Matthias Kirsten, Nathalia affil: Dermatologikum Hamburg, Hamburg, Germany. sug: subj: Pyoderma Gangrenosum Therapy Plasma Gases Therapeutic Use Cold Therapeutic Use Treatment Outcomes Evaluation Patient Preference Evaluation Patient-Reported Outcomes Evaluation Wound Care Methods Human Female Male Middle Age Aged Pilot Studies Randomized Controlled Trials Random Assignment Control Group Treatment Duration Visual Analog Scaling Summated Rating Scaling Outpatients Wound Assessment Wound Measurement Wound Healing Bandages and Dressings Pain Quality of Life T-Tests Mann-Whitney U Test Wilcoxon Rank Sum Test Chi Square Test Fisher's Exact Test Analysis of Variance Paired T-Tests Effect Size Comparative Studies Correlation Coefficient Data Analysis Software Descriptive Statistics Middle Aged: 45-64 years Aged: 65+ years Female Male ab: Objective: The application of cold atmospheric plasma (CAP) has been described as a promising therapeutic approach for wound healing. Its use in immunologically mediated wounds such as pyoderma gangrenosum (PG) has not yet been sufficiently investigated. This pilot study aimed to evaluate the efficacy, tolerability, patient preferences, and patient-reported outcomes of CAP in PG. Method: This monocentric, open-label, randomised and controlled pilot study included patients with PG. The treatment phase lasted 12 weeks, with two CAP treatments per week (for patients in the treatment group (TG), versus patients in the control group (CG) who received standard of care only) and five documented study visits. Effects on wound status and patient experience—including pain reduction, improvement in quality of life, and perceived treatment benefit—were assessed. Results: Both the TG and the CG comprised 10 patients each. In the TG, a statistically significant reduction in fibrin coatings was observed between Visit 1 and Visit 5 (z=–2.060; p<0.025; n=6; d=0.84). While not statistically significant under the predefined threshold (a=0.025), necrosis showed a trend toward reduction (p=0.039). A significant reduction in pain was also observed between Visit 1 and Visit 5 in the TG (z=–2.03; p<0.025; n=5; d=0.91) Conclusion: The results of this pilot study suggest that CAP is a safe and well tolerated treatment option for PG, and may reduce wound pain over the course of treatment. There is evidence that CAP may have a beneficial effect on the status of the wound in PG. Double-blinded randomised controlled trials, including larger cohorts and outcome-oriented randomisation, are needed to further clarify the therapeutic potential of CAP in PG. pubtype: Academic Journal doctype: pictorial research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|