Evaluation of Citral and Green Silver Nanoparticles From Cymbopogon citratus Extract on Biochemical Profile and Nrf2 Gene Expression in Liver Tissue of Type 2 Diabetic Rats.
The aim of this study was to evaluate the antioxidant effects of Cymbopogon citratus, citral, and green‐synthesized silver nanoparticles derived from the extract in mitigating oxidative stress–induced liver damage in diabetes mellitus. Seventy rats were randomly split into seven groups: a control gr...
| Published in: | BioMed Research International Vol. 2025; pp. 1 - 11 |
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| Main Authors: | , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
10/14/2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188672144&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188672144 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 10/14/2025 vid: 2025 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 188672144 188672144 188672144 10.1155/bmri/9266092 188672144 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Evaluation of Citral and Green Silver Nanoparticles From Cymbopogon citratus Extract on Biochemical Profile and Nrf2 Gene Expression in Liver Tissue of Type 2 Diabetic Rats. aug: au: Khatinasab, Shadi Kazemipour, Nasrin Noorbakhsh, Mohammad Foad Nazifi, Saeed Faraji, Milad Ahmadi, Nasrollah Badraoui, Riadh affil: Department of Basic Sciences,, School of Veterinary Medicine,, Shiraz University,, Shiraz, Iran, shirazu.ac.ir sug: subj: Plant Extracts Pharmacodynamics Lemon Grass Pharmacodynamics Nanoparticles Terpenes Pharmacodynamics Antioxidants NF-E2-Related Factor 2 Metabolism Gene Expression Drug Effects Liver Drug Effects Diabetes Mellitus, Type 2 Drug Therapy Oxidative Stress Drug Effects Silver Animal Studies Rats Olive Oil Metformin Liver Function Tests Aspartate Aminotransferase Alkaline Phosphatase Blood Glucose Metformin Administration and Dosage Alanine Aminotransferase Reverse Transcriptase Polymerase Chain Reaction Analysis of Variance Post Hoc Analysis Funding Source ab: The aim of this study was to evaluate the antioxidant effects of Cymbopogon citratus, citral, and green‐synthesized silver nanoparticles derived from the extract in mitigating oxidative stress–induced liver damage in diabetes mellitus. Seventy rats were randomly split into seven groups: a control group of healthy rats received normal saline, a cosolvent group of Type 2 diabetics received olive oil, a negative control group of Type 2 diabetics, and groups of diabetic rats receiving various treatments: metformin (100 mg/kg), Cymbopogon citratus extract (30 mg/kg), citral (30 mg/kg), and green‐synthesized silver nanoparticles (30 mg/kg). Type 2 diabetes was induced in rats using 90 mg/kg of nicotinamide and 65 mg/kg of streptozotocin. After 6 weeks, the rats were anesthetized to extract blood samples. The serum levels of the liver function test (serum glutamic–oxaloacetic transaminase, serum glutamic–pyruvic transaminase, and alkaline phosphatase) were measured. They were then euthanized by CO2 inhalation. Liver tissue was used to investigate histopathology, antioxidant activity, and Nrf2 gene expression. In the diabetes group, liver function tests increased, while TAC decreased and MDA increased (p < 0.05). The expression of the Nrf2 gene decreased compared to the control group (p < 0.05). In the treatment groups, the liver function tests and MDA decreased, while TAC and the expression of the Nrf2 gene increased compared to the Type 2 diabetes group (p < 0.05). The histopathological examination showed a return to normal condition. The study found that Cymbopogon citratus, specifically citral and green‐synthesized silver nanoparticles, effectively mitigated oxidative stress–induced liver damage in diabetes. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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