Study on Serological Markers and Brain Structural Changes in Early Clinical Stage of Alzheimer’s Disease in Cold Regions.
Background: Subjective cognitive decline (SCD) and mild cognitive impairment (MCI) represent early clinical manifestations of Alzheimer’s disease (AD). Recent research has highlighted serum markers and changes in brain structure as promising tools for diagnosing cerebral disorders. This study invest...
| Published in: | Actas Espanolas de Psiquiatria Vol. 53; no. 4; pp. 669 - 683 |
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| Main Authors: | , , , |
| Format: | Article |
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Maria Lopez-Ibor
2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=188690544&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 188690544 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11399287 IVZ jtl: Actas Espanolas de Psiquiatria issn: 11399287 maglogo: N pubinfo: dt: 2025 vid: 53 iid: 4 pid: 80014 pub: Maria Lopez-Ibor artinfo: ui: 188690544 10.62641/aep.v53i4.1936 ppf: 669 ppct: 14 formats: fmt: @attributes: type: P size: 2.1MB tig: atl: Study on Serological Markers and Brain Structural Changes in Early Clinical Stage of Alzheimer’s Disease in Cold Regions. aug: au: Yin, Changhao Chen, Lingyu Wang, Jianhang Zhao, Weina affil: Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical College, 157000 Mudanjiang, Heilongjiang, China. Center for Mudanjiang North Medicine Resource Development and Application Collaborative Innovation, 157000 Mudanjiang, Heilongjiang, China. su: Alzheimer's disease Mild cognitive impairment Cognition disorders Apolipoprotein E Extracellular vesicles Biomarkers Cold regions sug: subj: Alzheimer's disease Mild cognitive impairment Cognition disorders Apolipoprotein E Extracellular vesicles Biomarkers Cold regions keyword: Alzheimer’s disease amyloid β protein apolipoproteins E cold climate magnetic resonance imaging microRNA ab: Background: Subjective cognitive decline (SCD) and mild cognitive impairment (MCI) represent early clinical manifestations of Alzheimer’s disease (AD). Recent research has highlighted serum markers and changes in brain structure as promising tools for diagnosing cerebral disorders. This study investigated serum biomarkers and brain structural changes in the early clinical stage of AD affected individuals residing in a cold region. Methods: Clinical data from patients with SCD or MCI and from normal controls, who were tested at Hongqi Hospital Affiliated to Mudanjiang Medical College from January 2018 to December 2023, were retrospectively analysed. According to clinical classification, the patients were categorised into SCD (n = 60), MCI (n = 60) and normal control groups (n = 70). The magnetic resonance imaging data, serum levels of amyloid β 1-40/42, exosomal miRNA (34a/34c/135a) and apolipoprotein E (ApoE) genotype were collected and analysed. Results: The mean diffusivity values in the bilateral parahippocampal gyrus, inferior longitudinal bundle, right inferior fronto-occipital tract and posterior cingulate gyrus in the SCD group decreased relative to those of the MCI group (all p < 0.05). Conversely, the fractional anisotropy values in the bilateral parahippocampal gyrus, inferior fronto-occipital tract, inferior longitudinal tract and posterior cingulate gyrus in the SCD group increased (all p < 0.05). Compared with the normal control group, the MCI and SCD groups showed elevated levels of serum Aβ1-40 and Aβ1-42 and exosomal miRNA-34a and miRNA-34c (all p < 0.05) and decreased exosomal miRNA-135a expression (p < 0.05). The serum levels of Aβ1-40, Aβ1-42 and exosomal miRNA-34a and miRNA-34c in the SCD group were lower than those in the MCI group (all p < 0.05), whereas miRNA-135a level was higher (p < 0.05). The proportions of ApoE ε3/3 in the normal control group was the highest (62.86%), and the proportions of ApoE ε2/4, ε3/4 and ε4/4 in the MCI group were the highest (38.33%, 26.67% and 10.00%, respectively). Conclusion: Changes in brain structure and serum biomarkers (miRNAs and Aβ) are evident in the early stages of AD, and the proportion of ApoE alleles vary in early AD. These findings may contribute to the development of an early recognition model for AD. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Actas Espanolas de Psiquiatria holder: Maria Lopez-Ibor dt: @attributes: year: 2025 holdings: @attributes: islocal: N |
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