High-amylose barley bread improves postprandial glycemia compared to regular barley and wheat bread in subjects with or without type 2 diabetes.
Background: Genetically modified (GMO) high-amylose barley lowers postprandial glucose. Since certain EU countries do not allow GMO barley, we therefore assessed if high-amylose barley made from traditional breeding (Lean Baking Barley, LBB) lowers postprandial glucose compared to bread made from re...
| Publicado en: | European Journal of Clinical Nutrition Vol. 79; no. 10; pp. 1000 - 1007 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Oct2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188780096&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188780096 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09543007 EUC jtl: European Journal of Clinical Nutrition issn: 09543007 maglogo: N pubinfo: dt: Oct2025 vid: 79 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 188780096 186771414 188780096 188780096 10.1038/s41430-025-01646-6 188780096 ppf: 1000 ppct: 7 formats: tig: atl: High-amylose barley bread improves postprandial glycemia compared to regular barley and wheat bread in subjects with or without type 2 diabetes. aug: au: Bohl, Mette Gregersen, Søren Li, Zhihang Blennow, Andreas Hebelstrup, Kim H. Hermansen, Kjeld affil: https://ror.org/040r8fr65 Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus N, 8200, Aarhus, Denmark sug: subj: Glucans Therapeutic Use Barley Therapeutic Use Postprandial Period Drug Effects Glycemic Index Drug Effects Wheat Therapeutic Use Bread Analysis Diabetes Mellitus, Type 2 Diet Therapy Food, Genetically Modified Therapeutic Use Satiation Incretins Metabolism Lipids Metabolism Glucagon Metabolism Taste Human Male Female Adolescence Adult Middle Age Aged Aged, 80 and Over Randomized Controlled Trials Crossover Design Appetite Analysis of Variance Food Preferences Glycated Hemoglobin Statins Antihypertensive Agents Single-Blind Studies Random Assignment Insulin Blood Triglycerides Metabolism Glucagon-Like Peptides Metabolism Pretest-Posttest Design Data Analysis Software Enzyme-Linked Immunosorbent Assay Funding Source Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Background: Genetically modified (GMO) high-amylose barley lowers postprandial glucose. Since certain EU countries do not allow GMO barley, we therefore assessed if high-amylose barley made from traditional breeding (Lean Baking Barley, LBB) lowers postprandial glucose compared to bread made from regular barley (RB) or wheat (WF) in individuals with or without type 2 diabetes (T2D). Methods: In a randomised crossover design, 38 participants (18 T2D and 20 non-T2D) consumed 160 g of bread made from 100% LBB, RB, or WF. Postprandial metabolic responses, appetite and bread perception were measured. A mixed model ANOVA was used for analysis. Results: LBB bread reduced 4 h postprandial glucose measured as incremental area under the curve (iAUC) by 41% and 39% vs. WF and RB bread in T2D and by 28% and 32% in non-T2D (all, P < 0.05). In T2D, LBB reduced postprandial insulin (iAUC) by 52% and 38% vs. WF and RB, and by 60% vs. WF in non-T2D (all, P < 0.05). Postprandial GIP (iAUC) was lower after LBB in both groups vs. RB and WF (P < 0.05). GLP-1 (iAUC) and FFA (tAUC) were lower after LBB vs. WF in non-T2D (P < 0.05), but not in T2D. Appetite scores were similar for all breads. Overall liking was higher for WF but did not differ between barley types. Conclusion: LBB breads reduce postprandial glucose and insulin compared to RB and WF bread in individuals irrespective of T2D. LBB may have potential as a functional food in prevention and management of T2D. ClinicalTrails.gov registration: NCT04702672. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|