Effects of hyperprolactinemia and bromocriptine treatment on cerebral blood flow and functional brain States.
Purpose: Hyperprolactinemia (HPRL) affects both reproductive function and the central nervous system. However, its specific effects on brain function and blood flow remain unclear. Methods: This study used multimodal magnetic resonance imaging to examine cerebral blood flow (CBF) and functional netw...
| Publicado en: | Neuroradiology Vol. 67; no. 9; pp. 2551 - 2562 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188799154&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188799154 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Sep2025 vid: 67 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 188799154 186710997 188799154 188799154 10.1007/s00234-025-03686-y 188799154 ppf: 2551 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of hyperprolactinemia and bromocriptine treatment on cerebral blood flow and functional brain States. aug: au: Xu, Manxi Liu, Bing Yang, Aocai Luan, Jixin Li, Shijun Zhu, Li Shu, Ni Ouyang, Gaoxiang Wang, Yuli Wang, Yao Ma, Guolin affil: https://ror.org/037cjxp13 Department of Radiology, China-Japan Friendship Hospital, No.2 Yinghua East Road, Chaoyang District, Beijing 100029, China, beijing, China sug: subj: Bromocriptine Therapeutic Use Prolactin Hyperpituitarism Drug Therapy Brain Physiology Brain Blood Supply Cerebrovascular Circulation Evaluation Large-Scale Brain Networks Physiology Functional Connectivity Cerebrovascular Circulation Drug Effects Hyperpituitarism Physiopathology Human Funding Source Male Female Adult Middle Age Functional Status Case Control Studies Prospective Studies Pretest-Posttest Design Brain Radiography Magnetic Resonance Imaging Descriptive Statistics Data Analysis Software ROC Curve T-Tests Mann-Whitney U Test Pearson's Correlation Coefficient Chi Square Test Two-Tailed Test Post Hoc Analysis Enzyme-Linked Immunosorbent Assay Dopamine Agonists Therapeutic Use Chemiluminescent Measurements Polyethylene Glycols Analysis Gray Matter Prefrontal Cortex Blood Supply Self-Rating Anxiety Scale Self-Rating Depression Scale Scales Psychological Tests Neuropsychological Tests Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Purpose: Hyperprolactinemia (HPRL) affects both reproductive function and the central nervous system. However, its specific effects on brain function and blood flow remain unclear. Methods: This study used multimodal magnetic resonance imaging to examine cerebral blood flow (CBF) and functional network characteristics in 32 HPRL patients, including those undergoing bromocriptine treatment, and 40 healthy controls. Results: Results revealed a significant reduction in global mean CBF in HPRL patients, particularly in the right inferior frontal gyrus, left middle temporal gyrus, and bilateral rectus gyrus. In contrast, the right middle frontal gyrus exhibited increased CBF. Following bromocriptine treatment, global CBF showed an upward trend. Additionally, the hierarchical structure of functional networks in HPRL patients was diminished and negatively correlated with serum prolactin levels, potentially related to reduced connectivity between the default mode and sensorimotor networks. Conclusion: These findings provide new insights into how HPRL and bromocriptine influence brain function, enhancing the understanding of the underlying neurophysiological mechanisms. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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