Histology of PFO-associated stroke thrombus compared to iliofemoral deep vein thrombus: an explorative study.
Purpose: A patent foramen ovale (PFO) is as a cause of thrombo-embolic stroke. It is thought that the thrombus originates from the venous circulation, although this has never been proven. The histological composition of the thrombus might help to identify its origin. The aim of this exploratory pilo...
| Published in: | Neuroradiology Vol. 67; no. 9; pp. 2321 - 2327 |
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| Main Authors: | , , , , , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Springer Nature
Sep2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188799157&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188799157 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Sep2025 vid: 67 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 188799157 186331455 188799157 188799157 10.1007/s00234-025-03693-z 188799157 ppf: 2321 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Histology of PFO-associated stroke thrombus compared to iliofemoral deep vein thrombus: an explorative study. aug: au: Immens, M. H. M. Stam, M. Dippel, D. W. J. Nijeholt, G. J. Lycklama à van der Worp, H. B. Jenniskens, S. van Rijn, M. J. de Leeuw, F. E. Cate, T. J. F.ten van Beusekom, H. M. M. Tuladhar, Anil M. affil: https://ror.org/05wg1m734 Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Radboud University Medical Center, Nijmegen, Netherlands sug: subj: Venous Thrombosis Pathology Stroke Etiology Heart Septal Defects, Atrial Complications Femoral Vein Pathology Ilium Blood Supply Ilium Pathology Human Funding Source Exploratory Research Pilot Studies Descriptive Statistics Retrospective Design Record Review Quantitative Studies Qualitative Studies Data Analysis Software Erythrocytes Fibrin Blood Platelets ab: Purpose: A patent foramen ovale (PFO) is as a cause of thrombo-embolic stroke. It is thought that the thrombus originates from the venous circulation, although this has never been proven. The histological composition of the thrombus might help to identify its origin. The aim of this exploratory pilot study is to compare the histological composition of thrombi of patients with PFO-associated stroke with venous thrombi from patients with iliofemoral deep venous thrombosis (DVT). Methods: We retrieved thrombi from the MR CLEAN Registry, a Dutch nationwide, multicenter, prospective registry of patients who underwent endovascular treatment for ischemic stroke. Furthermore DVT thrombi were obtained as fully anonymous waste material and analyzed retrospectively. Results: Thrombi were available for three patients treated for PFO-associated stroke and four patients treated for DVT. The thrombi of patients with PFO-associated stroke contained less red blood cells (RBC) and more fibrin and platelets (Fib + Plt) than those with DVT (30.2% vs. 91.3% RBC and 67.4% vs. 8.5% Fib + Plt). The PFO-associated stroke thrombi were most comparable to thrombi from the same cohort classified as cardioembolic (RBC 25.8% and 67.1% Fib + Plt). As this is a descriptive histological analysis, no definitive comparisons between different thrombi can be made. Conclusion: We observed that the composition of the three thrombi from patients with PFO-associated stroke differs from that of the four DVT thrombi in our cohort. Prospective studies are needed to determine whether thrombi in PFO-associated stroke are all similar in composition and share a similar pathophysiology with venous thrombi. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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