Barriers and facilitators to recruitment of rural patients to cancer clinical trials.

Background: Rural patients are significantly underrepresented in cancer clinical trials. A proper understanding of the barriers and facilitators to rural patient participation in cancer clinical trials is essential, especially in states like Texas where rural-urban disparity is prominent. Methods: E...

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Publicado en:Baylor University Medical Center Proceedings Vol. 38; no. 6; pp. 929 - 937
Autores principales: Thapar, Ruhi, Mulley, Rebecca, Ferriola, Nathaniel, Luan, Tiffany, Sanker, Richard, Wong, Lucas, Abel, Erika L., Go, Lisa
Formato: research systematic review tables/charts Journal Article
Publicado: Taylor & Francis Ltd Nov2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Nov2025
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      pub: Taylor & Francis Ltd
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        atl: Barriers and facilitators to recruitment of rural patients to cancer clinical trials.
      aug:
        au:
          Thapar, Ruhi
          Mulley, Rebecca
          Ferriola, Nathaniel
          Luan, Tiffany
          Sanker, Richard
          Wong, Lucas
          Abel, Erika L.
          Go, Lisa
        affil: Department of Student Affairs, Baylor College of Medicine, Houston, Texas, USA
      sug:
        subj:
          Research Subject Recruitment
          Healthcare Disparities
          Patient Participation
          Cancer Patients Psychosocial Factors
          Rural Population Psychosocial Factors
          Clinical Trials
          Urban Areas
          Human
          Texas
          Systematic Review
          Medline
          Embase
          CINAHL Database
          Cochrane Library
          Psycinfo
          Health Knowledge
          Oncologists
          Transportation of Patients
          Communication
          Eligibility Determination
          Caregiver Support
          Support, Social
          Descriptive Statistics
          Odds Ratio
          Thematic Analysis
      ab: Background: Rural patients are significantly underrepresented in cancer clinical trials. A proper understanding of the barriers and facilitators to rural patient participation in cancer clinical trials is essential, especially in states like Texas where rural-urban disparity is prominent. Methods: EBSCO Medline, Embase, CINAHL, Cochrane, and PsycInfo were systematically searched for articles. A total of 2663 articles were screened, yielding 20 articles for study. Results: A systematic review of the literature revealed that barriers and facilitators to cancer clinical trial participation by rural populations are present at the patient, physician, and healthcare system levels. Notable barriers found in this review include the burden of travel, lack of patient knowledge about clinical trial participation, insufficient provider communication and awareness of current trials, and strict eligibility criteria. Promising facilitators include caregiver support, close physician support and contact, and programs to increase patient understanding of clinical trials. Conclusion: Further elucidating barriers to ascertain why rural patients have less participation in clinical trials, and exploring which facilitators need to be further explored, could allow for effectively harnessing the power of facilitators in the pursuit of lessening disparities and improving cancer outcomes for rural patients.
      pubtype: Academic Journal
      doctype:
        research
        systematic review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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