A Retrospective Within-Subjects Analysis of Vancomycin Bayesian Modeling With Pre-steady-State vs Steady-State Concentrations.
Background: Bayesian modeling of vancomycin can estimate 24-hour area under the curve (AUC24) using pre-steady-state concentrations. Limited literature exists comparing Bayesian AUC24 calculations derived from steady-state versus pre-steady-state concentrations. Objective: To assess the agreement be...
| Publicado en: | Journal of Pharmacy Technology Vol. 41; no. 6; pp. 268 - 276 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188855761&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188855761 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 87551225 G2J jtl: Journal of Pharmacy Technology issn: 87551225 maglogo: Y pubinfo: dt: Dec2025 vid: 41 iid: 6 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 188855761 187441713 188855761 188855761 10.1177/87551225251362731 188855761 ppf: 268 ppct: 8 formats: tig: atl: A Retrospective Within-Subjects Analysis of Vancomycin Bayesian Modeling With Pre-steady-State vs Steady-State Concentrations. aug: au: Covington, Elizabeth W. Chae, Jihyun L. Gunter, Sarah Grace affil: Harrison College of Pharmacy, Auburn University, Auburn, AL, USA sug: subj: Vancomycin Administration and Dosage Vancomycin Blood Probability Biological Availability Dosage Calculation Vancomycin Analysis Human Retrospective Design Record Review Male Female Middle Age Aged Aged, 80 and Over Prospective Studies Linear Regression Data Analysis Software Descriptive Statistics Drug Monitoring Vancomycin Pharmacokinetics Confidence Intervals Wilcoxon Signed Rank Test Post Hoc Analysis Chi Square Test Health Facilities Alabama Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Background: Bayesian modeling of vancomycin can estimate 24-hour area under the curve (AUC24) using pre-steady-state concentrations. Limited literature exists comparing Bayesian AUC24 calculations derived from steady-state versus pre-steady-state concentrations. Objective: To assess the agreement between vancomycin AUC24 calculations using pre-steady-state versus steady-state concentrations, employing Bayesian modeling. Methods: This retrospective within-subjects cohort study included patients with at least 1 pre-steady-state and 1 steady-state vancomycin concentration. Patients with age >100 years, weight <40 kg, height <60 inches, or renal dysfunction were excluded. The steady-state AUC24 from dosing software was documented with and without hiding steady-state levels from calculations. The primary outcome was agreement between AUC24 without levels hidden compared with AUC24 with steady-state levels hidden from analysis. Secondary outcomes included the agreement between AUC24 with pre-steady-state levels hidden and the percentage of patients with matching AUC24 categories. The AUC24 agreement was evaluated via Bland-Altman plot and bias via linear regression. Statistical tests were performed using SPSS statistics software (IBM Corp). Results: A total of 93 patients were included. The mean difference in AUC24 compared to AUC24 with steady-state levels hidden was 8.8 mg*h/L, and with pre-steady-state levels hidden, it was −3.7 mg*h/L. Linear regression analysis indicated a proportional bias when steady-state levels were hidden (β = 0.22; P = 0.038) but not when pre-steady-state levels were hidden. Category mismatch occurred more often when steady-state levels were hidden vs when pre-steady-state levels were hidden (26% vs 8%; P < 0.001). Conclusion and Relevance: The study demonstrated overall agreement between AUC24 compared to AUC24 with steady-state levels hidden. The mean differences in AUC24 estimates were small, no matter which level was hidden, although tighter limits of agreement were observed when steady-state levels were utilized in Bayesian calculations. Further research with larger sample sizes is necessary. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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