Fish Acellular Dermal Matrix Promotes Repair of Full‐Thickness Skin Defects in Mice and Bama Pigs.
This study aimed to develop an acellular dermal matrix derived from tilapia skin and evaluate its potential as a bioscaffold for skin wound repair. Structural and compositional changes before and after decellularisation were assessed through histological staining, electron microscopy and immunologic...
| Publicado en: | Wound Repair & Regeneration Vol. 33; no. 5; pp. 1 - 17 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Sep/Oct2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188875048&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188875048 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Sep/Oct2025 vid: 33 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 188875048 188875048 188875048 10.1111/wrr.70091 188875048 ppf: 1 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Fish Acellular Dermal Matrix Promotes Repair of Full‐Thickness Skin Defects in Mice and Bama Pigs. aug: au: Wang, Zi‐Yi Lin, Zi‐Hao Liu, Ruo‐Tao Liu, Zhe Peng, Hao Hu, Zhi‐Chao Fu, Wei‐Qing Jin, Li‐Ming Zhang, Chang‐Qing Tang, Qian Zhu, Zhen‐Zhong Wei, Xiao‐Juan affil: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China sug: subj: Fish Skin, Artificial Skin Injuries Skin Transplantation Methods Wound Healing Extracellular Matrix Biocompatible Materials Animal Studies Mice Swine China Tissue Engineering Tissue Scaffolds Collagen Cell Proliferation Endothelial Cells Fibroblasts Gene Expression Profiling Models, Biological Neovascularization, Physiologic Enzyme-Linked Immunosorbent Assay Staining and Labeling Paraffin Embedding Blotting, Western T-Tests One-Way Analysis of Variance Two-Way Analysis of Variance Statistical Significance Data Analysis Software Descriptive Statistics Funding Source ab: This study aimed to develop an acellular dermal matrix derived from tilapia skin and evaluate its potential as a bioscaffold for skin wound repair. Structural and compositional changes before and after decellularisation were assessed through histological staining, electron microscopy and immunological analysis. The matrix exhibited low immunogenicity, preserved extracellular matrix architecture and retained key bioactive components. In vitro, the matrix significantly promoted cell proliferation, migration, and tube formation in human umbilical vein endothelial cells and human foreskin fibroblasts. In vivo, full‐thickness skin defect models in Balb/c mice and Bama pigs demonstrated that the tilapia‐derived matrix not only accelerated wound closure but also improved the quality of tissue regeneration by enhancing collagen deposition and vascularisation. Compared to the commercial porcine‐derived matrix, the fish‐derived scaffold exhibited superior regenerative outcomes. Notably, transcriptomic profiling of wound tissue revealed that the matrix modulated a range of biological pathways, including immune regulation, extracellular matrix remodelling and angiogenesis, indicating a multifaceted interaction between the biomaterial and host tissue. These findings underscore the excellent biocompatibility and therapeutic efficacy of the tilapia‐derived matrix, supporting its potential as a safe, economical and sustainable bioscaffold for clinical skin repair. The inclusion of a large animal model provides critical translational relevance due to the anatomical and physiological similarity between porcine and human skin, while transcriptomic analysis offers valuable mechanistic insights into matrix–tissue interactions. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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