Myrtus communis reduces radiation-induced genitourinary histopathological damage and apoptosis in rats: TROD-GROG-004 Study.
Objective: To investigate the radioprotective and prophylactic effects of Myrtus communis (MC) in kidney, bladder, and ovary samples in an animal model. Materials and Methods: Female rats (n=30) were divided into four groups. The control group (C) (n=6) received only oral saline (SF) for four days....
| Published in: | Marmara Medical Journal Vol. 38; no. 3; pp. 190 - 198 |
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| Main Authors: | , , , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Marmara Medical Journal
Oct2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188888845&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188888845 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10191941 787L jtl: Marmara Medical Journal issn: 10191941 maglogo: N pubinfo: dt: Oct2025 vid: 38 iid: 3 pid: 47510 pub: Marmara Medical Journal artinfo: ui: 188888845 188888845 188888845 10.5472/marumj.1798589 188888845 ppf: 190 ppct: 8 formats: tig: atl: Myrtus communis reduces radiation-induced genitourinary histopathological damage and apoptosis in rats: TROD-GROG-004 Study. aug: au: OZKURT, Selnur DOGAN, Bedriye OZYILMAZ, Nagehan AYKAC, Aslı ERTAS, Busra SEN, Ali CEYLAN, Cemile ERCAN, Feriha ATASOY, Beste M. affil: Department of Radiation Oncology, University Hospital Leuven, Leuven, Belgium sug: subj: Apoptosis Kidney Drug Effects Bladder Drug Effects Ovary Drug Effects Models, Biological Urogenital System Plant Extracts Pharmacodynamics Radiation, Ionizing Adverse Effects Animal Studies Rats Turkiye Funding Source Experimental Studies In Vivo Studies Comparative Studies Post Hoc Analysis One-Way Analysis of Variance Data Analysis Software Descriptive Statistics Blotting, Western Staining and Labeling Fluorescent Dyes Antiinflammatory Agents Pharmacodynamics Antioxidants Pharmacodynamics Caspases ab: Objective: To investigate the radioprotective and prophylactic effects of Myrtus communis (MC) in kidney, bladder, and ovary samples in an animal model. Materials and Methods: Female rats (n=30) were divided into four groups. The control group (C) (n=6) received only oral saline (SF) for four days. Ionizing radiation (IR) groups were organized as follows: "IR group (IR)" (n=8) received oral SF for four days starting on the day of administration; "MC treatment group (MC-tx)" (n=8) received oral MC for four days beginning on the day of irradiation; and "MC pretreatment group (MC-Ptx)" (n=8) received oral MC for a total of eight days, starting four days before irradiation. MC was administered via oral gavage. Irradiation was performed at 10 Gray (Gy) in a single dose. On the fourth day of irradiation, all rats were sacrificed, the tissues were examined histopathologically, and caspase-9 and caspase-3 levels were examined using western blotting to assess mitochondrial apoptosis. Results: Radiation-induced damage decreased across all treatment groups. Caspase-9 and caspase-3 levels were significantly lower in the MC-Ptx and MC-tx groups compared to the IR group in all tissues (p<0.01). Conclusion: Myrtus communis significantly ameliorated IR-induced damage to genitourinary tissues by both prophylactic and therapeutic applications. Therefore, the findings of this study may contribute to the development of new strategies in radioprotection. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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