Navigating the Controversies and Complexities of Implementing Lecanemab in the Veterans Affairs Health System.

The article focuses on the evolving landscape of Alzheimer's disease (AD) diagnosis and treatment, particularly the implementation of anti-amyloid therapies like lecanemab within the Veterans Health Administration (VHA). It highlights the shift from clinical diagnosis to biomarker-based confirmation...

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Publicado en:Journal of the American Geriatrics Society Vol. 73; no. 10; pp. 2983 - 2986
Autores principales: Yang, Mia, Chodosh, Joshua
Formato: Artículo
Publicado: Wiley-Blackwell Oct2025
Materias:
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Oct2025
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      pub: Wiley-Blackwell
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        atl: Navigating the Controversies and Complexities of Implementing Lecanemab in the Veterans Affairs Health System.
      aug:
        au:
          Yang, Mia
          Chodosh, Joshua
        affil:
          Wake Forest University School of Medicine, Atrium Health Neurosciences‐ Charlotte, Wake Forest Baptist Internal Medicine‐ Geriatrics, Advocate Health, Winston Salem, USA
          NYU Grossman School of Medicine, Department of Medicine, New York, USA
          VA New York Harbor Healthcare System, New York, USA
      su:
        United States. Dept. of Veterans Affairs
        Human services programs
        Conflict (Psychology)
        Cost benefit analysis
        Therapeutic use of monoclonal antibodies
        Alzheimer's disease
        Medical care of veterans
        Surveys
        Conceptual structures
        Amyloid beta-protein precursor
        Chemical inhibitors
      sug:
        subj:
          Human services programs
          Conflict (Psychology)
          Cost benefit analysis
          United States. Dept. of Veterans Affairs
          Administration of Veterans' Affairs
          Therapeutic use of monoclonal antibodies
          Alzheimer's disease
          Medical care of veterans
          Surveys
          Conceptual structures
          Amyloid beta-protein precursor
          Chemical inhibitors
      keyword:
        anti‐amyloid therapies
        implementation
        lecanemab
        anti‐amyloid therapies
        implementation
        lecanemab
      ab: The article focuses on the evolving landscape of Alzheimer's disease (AD) diagnosis and treatment, particularly the implementation of anti-amyloid therapies like lecanemab within the Veterans Health Administration (VHA). It highlights the shift from clinical diagnosis to biomarker-based confirmation, emphasizing the complexities of diagnosing AD/ADRD due to co-existing conditions. The survey conducted by O'Donnell et al. reveals both facilitators and barriers to implementing lecanemab, including the need for extensive infrastructure and interdisciplinary collaboration. The article underscores the importance of proactive engagement from geriatricians in ensuring safe and effective delivery of these therapies, while also acknowledging the challenges posed by the modest efficacy and safety concerns associated with lecanemab.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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