Psychotropic pharmacogenetics in adult populations: From basic science to clinical trials and health economics – An evidence-based overview for decision makers.
Psychotropic pharmacogenetics (PGx) offers significant potential advancements in psychiatric care by optimising medication selection and dosing based on genetic factors. This perspective article highlights the clinical utility, health economic implications and implementation challenges of psychotrop...
| Publicado en: | Australian & New Zealand Journal of Psychiatry Vol. 59; no. 11; pp. 950 - 957 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | review Journal Article |
| Publicado: |
Sage Publications Inc.
Nov2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188922802&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188922802 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00048674 7ZU jtl: Australian & New Zealand Journal of Psychiatry issn: 00048674 maglogo: Y pubinfo: dt: Nov2025 vid: 59 iid: 11 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 188922802 187774579 188922802 188922802 10.1177/00048674251369625 188922802 ppf: 950 ppct: 7 formats: tig: atl: Psychotropic pharmacogenetics in adult populations: From basic science to clinical trials and health economics – An evidence-based overview for decision makers. aug: au: Truong, Trang TT Lago, Juliana Neil, Jennifer Wilkes, Fiona A Barnes, Russell Hopwood, Malcolm Singh, Ajeet B affil: Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Melbourne, VIC, Australia sug: subj: Pharmacogenetics Methods Pharmacogenetics Economics Psychotropic Drugs Therapeutic Use Psychotropic Drugs Adverse Effects Psychotropic Drugs Economics Mental Disorders Drug Therapy Mental Disorders Familial and Genetic Individualized Medicine Methods Individualized Medicine Economics Depression Drug Therapy Depression Familial and Genetic Schizophrenia Drug Therapy Schizophrenia Familial and Genetic Adverse Drug Event Prevention and Control Oxidoreductases Metabolism Cost Benefit Analysis Implementation Science Australia Genetic Screening Health Policy ab: Psychotropic pharmacogenetics (PGx) offers significant potential advancements in psychiatric care by optimising medication selection and dosing based on genetic factors. This perspective article highlights the clinical utility, health economic implications and implementation challenges of psychotropic PGx, proposing that its broader implementation could enhance patient outcomes and reduce healthcare costs. Landmark studies show that PGx-guided care results in fewer adverse drug reactions and improved medication efficacy, with substantial cost savings compared to traditional prescribing methods. However, implementation barriers persist, particularly in Australia, where knowledge gaps, limited clinical guidelines and funding constraints hinder adoption. Despite challenges such as industry bias and limited data on non-antidepressant psychotropics, robust clinical and economic evidence supports the expanded use of psychotropic PGx, with emerging combinatorial approaches offering promise for future psychiatric treatment. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|