18F-FDG PET/CT volumetric parameter predicts prognosis for neuroblastoma with MYCN gain.
Purpose: The aim of the study was to evaluate the value of 18F-FDG PET/CT metabolic parameters in neuroblastoma (NB) with MYCN gain. Methods: A retrospective analysis was conducted on 87 patients with NB (29 with MYCN gain and 58 with MYCN normal). The region of interest of primary tumors were manua...
| Publicado en: | Abdominal Radiology Vol. 50; no. 11; pp. 5614 - 5628 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188952028&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188952028 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Nov2025 vid: 50 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 188952028 184860457 10.1007/s00261-025-04973-1 188952028 ppf: 5614 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: 18F-FDG PET/CT volumetric parameter predicts prognosis for neuroblastoma with MYCN gain. aug: au: Li, Siqi Liu, Jun Wang, Guanyun Kan, Ying Wang, Wei Yang, Jigang affil: https://ror.org/013xs5b60 Nuclear Medicine Department, Beijing Friendship Hospital, Capital Medical University, Beijing, China sug: ab: Purpose: The aim of the study was to evaluate the value of 18F-FDG PET/CT metabolic parameters in neuroblastoma (NB) with MYCN gain. Methods: A retrospective analysis was conducted on 87 patients with NB (29 with MYCN gain and 58 with MYCN normal). The region of interest of primary tumors were manually delineated using 3D slicer™ software, and 18F-FDG PET/CT metabolic parameters, including SUVmax, SUVpeak, SUVmean, MTV and TLG were extracted. Logistic regression analyses were used to identify the relationship between 18F-FDG PET/CT metabolic parameters and MYCN gain. Cox proportional hazards regression models were used to assess the associations between 18F-FDG PET/CT metabolic parameters and EFS and OS. Survival curves were generated using the Kaplan-Meier method, and differences in survival between groups were compared using the log-rank test. Results: A total of 87 NB patients [median age: 40 (20–56) months; 48 girls and 39 boys] were evaluated. Logistic regression analyses revealed that MTV (>133.3 cm3) was an independent predictor of MYCN gain. During the follow-up period of 22 (2–70) months, 21 patients died and 37 patients experienced disease recurrence or progression. Cox proportional hazards regression analyses showed that MTV, in combination with PHOX2B, was an independent prognostic factor for EFS and OS in NB patients with MYCN-gain. Patients with high MTV exhibited significantly shorter EFS and OS compared to those with low MTV. Conclusion: The volumetric parameter MTV derived from 18F-FDG PET/CT imaging can predict MYCN gain in NB patients and provide valuable prognostic information for patients with MYCN-gain NB. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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