Gaze behavior, facial emotion processing, and neural underpinnings: A comparison of adolescents with autism spectrum disorder and conduct disorder.
Background: Facial emotion processing deficits and atypical eye gaze are often described in individuals with autism spectrum disorder (ASD) and those with conduct disorder (CD) and high callous unemotional (CU) traits. Yet, the underlying neural mechanisms of these deficits are still unclear. The ai...
| Publicado en: | Journal of Child Psychology & Psychiatry Vol. 66; no. 11; pp. 1664 - 1675 |
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| Autores principales: | , , , , , , , , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Wiley-Blackwell
Nov2025
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=189002499&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 189002499 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00219630 JYY jtl: Journal of Child Psychology & Psychiatry issn: 00219630 maglogo: Y pubinfo: dt: Nov2025 vid: 66 iid: 11 pid: 480 pub: Wiley-Blackwell artinfo: ui: 189002499 10.1111/jcpp.14172 ppf: 1664 ppct: 11 formats: tig: atl: Gaze behavior, facial emotion processing, and neural underpinnings: A comparison of adolescents with autism spectrum disorder and conduct disorder. aug: au: Tkalcec, Antonia Baldassarri, Alessandro Junghans, Alex Somasundaram, Vithusan Menks, Willeke M. Fehlbaum, Lynn V. Borbàs, Réka Raschle, Nora Seeger‐Schneider, Gudrun Jenny, Bettina Walitza, Susanne Cole, David M. Sterzer, Philipp Santini, Francesco Herbrecht, Evelyn Cubillo, Ana Stadler, Christina affil: Child and Youth Psychiatry, University Psychiatric Clinic, Basel, Switzerland Donders Institute for Brain, Cognition and Behaviour, Radboud University, and Radboud University Medical Centre, Nijmegen, The Netherlands Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland Child and Youth Psychiatry, Psychiatric University Clinic, University of Zurich, Zurich, Switzerland Translational Psychiatry, University Psychiatric Clinic, Basel, Switzerland Radiological Physics Department, University Hospital, Basel, Switzerland su: Switzerland Adolescent development Parents Task performance Autism Interviewing Emotions Behavior disorders in children Caregivers Adolescence Brain physiology Research funding Data analysis Neurophysiology Eye movement measurements Questionnaires Multiple regression analysis Magnetic resonance imaging Research methodology Child Behavior Checklist Statistics Asperger's syndrome Comparative studies Neuroradiology Eye movements Face perception sug: subj: Adolescent development Parents Task performance Autism Interviewing Emotions Behavior disorders in children Caregivers Adolescence Switzerland Diagnostic Imaging Centers Brain physiology Research funding Data analysis Neurophysiology Eye movement measurements Questionnaires Multiple regression analysis Magnetic resonance imaging Research methodology Child Behavior Checklist Statistics Asperger's syndrome Comparative studies Neuroradiology Eye movements Face perception keyword: autism spectrum disorders brain activation Conduct disorder emotion processing eye gaze autism spectrum disorders brain activation Conduct disorder emotion processing eye gaze ab: Background: Facial emotion processing deficits and atypical eye gaze are often described in individuals with autism spectrum disorder (ASD) and those with conduct disorder (CD) and high callous unemotional (CU) traits. Yet, the underlying neural mechanisms of these deficits are still unclear. The aim of this study was to investigate if eye gaze can partially account for the differences in brain activation in youth with ASD, with CD, and typically developing youth (TD). Methods: In total, 105 adolescent participants (NCD = 39, NASD = 27, NTD = 39; mean age = 15.59 years) underwent a brain functional imaging session including eye tracking during an implicit emotion processing task while parents/caregivers completed questionnaires. Group differences in gaze behavior (number of fixations to the eye and mouth regions) for different facial expressions (neutral, fearful, angry) presented in the task were investigated using Bayesian analyses. Full‐factorial models were used to investigate group differences in brain activation with and without including gaze behavior parameters and focusing on brain regions underlying facial emotion processing (insula, amygdala, and medial prefrontal cortex). Results: Youth with ASD showed increased fixations on the mouth compared to TD and CD groups. CD participants with high CU traits tended to show fewer fixations to the eye region compared to TD for all emotions. Brain imaging results show higher right anterior insula activation in the ASD compared with the CD group when angry faces were presented. The inclusion of gaze behavior parameters in the model reduced the size of that cluster. Conclusions: Differences in insula activation may be partially explained by gaze behavior. This implies an important role of gaze behavior in facial emotion processing, which should be considered for future brain imaging studies. In addition, our results suggest that targeting gaze behavior in interventions might be potentially beneficial for disorders showing impairments associated with the processing of emotional faces. The relation between eye gaze, CU traits, and neural function in different diagnoses needs further clarification in larger samples. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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