Prevalence of Developmental, Psychiatric, and Neurologic Conditions in Older Siblings of Children with and without Autism Spectrum Disorder: Study to Explore Early Development.
This study evaluated developmental, psychiatric, and neurologic conditions among older siblings of children with and without autism spectrum disorder (ASD) to understand the extent of familial clustering of these diagnoses. Using data from the Study to Explore Early Development, a large multi-site c...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 55; no. 11; pp. 3785 - 3798 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189005186&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189005186 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Nov2025 vid: 55 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 189005186 178670581 189005186 189005186 10.1007/s10803-024-06464-6 189005186 ppf: 3785 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Prevalence of Developmental, Psychiatric, and Neurologic Conditions in Older Siblings of Children with and without Autism Spectrum Disorder: Study to Explore Early Development. aug: au: Fields, Victoria L. Tian, Lin H. Wiggins, Lisa D. Soke, Gnakub N. Overwyk, Katherine Moody, Eric Reyes, Nuri Shapira, Stuart K. Schieve, Laura A. affil: https://ror.org/042twtr12 National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailstop S106-4, 30341, Atlanta, GA, USA sug: subj: Developmental Disabilities Epidemiology Mental Disorders Diagnosed in Childhood Epidemiology Nervous System Diseases Epidemiology Siblings Autism Spectrum Disorder In Infancy and Childhood Child Development Human Secondary Analysis United States Interviews Case Control Studies Prevalence Male Female Child, Preschool Child Attention Deficit Hyperactivity Disorder Epidemiology Intellectual Disability Epidemiology Sensory Motor Integration Speech Disorders Epidemiology Language Disorders Epidemiology Sociodemographic Factors Income Anxiety Epidemiology Obsessive-Compulsive Disorder Epidemiology Bipolar Disorder Epidemiology Descriptive Statistics Poisson Distribution Chi Square Test Fisher's Exact Test Logistic Regression Depression Epidemiology Affective Disorders Epidemiology Epilepsy Epidemiology Seizures Epidemiology Bivariate Statistics Funding Source Questionnaires Child, Preschool: 2-5 years Child: 6-12 years Male Female ab: This study evaluated developmental, psychiatric, and neurologic conditions among older siblings of children with and without autism spectrum disorder (ASD) to understand the extent of familial clustering of these diagnoses. Using data from the Study to Explore Early Development, a large multi-site case-control study, the analyses included 2,963 children aged 2–5 years with ASD, other developmental disabilities (DD group), and a population-based control group (POP). Percentages of index children with older siblings with select developmental, psychiatric, and neurologic conditions were estimated and compared across index child study groups using chi-square tests and multivariable modified Poisson regression. In adjusted analyses, children in the ASD group were significantly more likely than children in the POP group to have one or more older siblings with ASD, developmental delay, attention-deficit/hyperactivity disorder, intellectual disability, sensory integration disorder (SID), speech/language delays, or a psychiatric diagnosis (adjusted prevalence ratio [aPR] range: 1.4–3.7). Children in the DD group were significantly more likely than children in the POP group to have an older sibling with most of the aforementioned conditions, except for intellectual disability and psychiatric diagnosis (aPR range: 1.4–2.2). Children in the ASD group were significantly more likely than children in the DD group to have one or more older siblings with ASD, developmental delay, SID, or a psychiatric diagnosis (aPR range: 1.4–1.9). These findings suggest that developmental disorders cluster in families. Increased monitoring and screening for ASD and other DDs may be warranted when an older sibling has a DD diagnosis or symptoms. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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