Antibiotic Resistance Identification Among the Patients with Helicobacter pylori Infection: A Cross-sectional Study from Iran.
Background: The successful treatment of Helicobacter pylori infection is warranted only by using appropriate antimicrobial agents determined after performing antibiotic susceptibility tests. Determining the susceptibility profile of antibiotics currently used against H. pylori in each geographical r...
| Publicado en: | Middle East Journal of Digestive Diseases Vol. 17; no. 3; pp. 167 - 175 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Iranian Association of Gastroenterology & Hepatology
Jul2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189074065&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189074065 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20085230 BG4K jtl: Middle East Journal of Digestive Diseases issn: 20085230 maglogo: N pubinfo: dt: Jul2025 vid: 17 iid: 3 pid: 70725 pub: Iranian Association of Gastroenterology & Hepatology artinfo: ui: 189074065 189074065 189074065 10.34172/mejdd.2025.427 189074065 ppf: 167 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Antibiotic Resistance Identification Among the Patients with Helicobacter pylori Infection: A Cross-sectional Study from Iran. aug: au: Hasanvand, Fatemeh Sisakhtpour, Javid Salehi, Mohamadreza Pestehei, Khalil Khodaparast, Sepideh affil: Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran sug: subj: Helicobacter Infections Drug Therapy Helicobacter Infections Microbiology Antibiotics Therapeutic Use Drug Resistance, Microbial Microbial Culture and Sensitivity Tests Iran Human Female Male Metronidazole Therapeutic Use Clarithromycin Therapeutic Use Amoxicillin Therapeutic Use Antiinfective Agents Therapeutic Use Biopsy Disease Susceptibility Tetracycline Therapeutic Use Drug Resistance, Multiple Dyspepsia Cross Sectional Studies Descriptive Statistics Female Male ab: Background: The successful treatment of Helicobacter pylori infection is warranted only by using appropriate antimicrobial agents determined after performing antibiotic susceptibility tests. Determining the susceptibility profile of antibiotics currently used against H. pylori in each geographical region can be very practically beneficial for all drug prescribers. Methods: In this cross-sectional study, we aim to identify the frequency of four antibiotics mainly referred to in the battle against H. pylori strains isolated from gastric biopsy specimens of 260 patients with dyspepsia referred to the gastroenterology clinics in Lorestan between 2020 and 2022, marking the first report from Iran. After culturing 260 gastric biopsy samples, H. pylori strains were identified using standard diagnostic methods. Results: The prevalence of antibiotic resistance among H. pylori isolates was reported using the antibiotic disc diffusion method with metronidazole, clarithromycin, amoxicillin, and tetracycline discs. Moreover, the minimum inhibitory concentration (MIC) of tetracycline-resistant H. pylori strains, screened by the diffusion disc method, was determined using the E-test method. Out of 260 biopsy samples, 187 (72%) samples (male: 42%, female: 58%) were H. pylori positive. The prevalence of antibiotic resistance rates among 187 isolates of H. pylori was as follows: metronidazole (87.7%, n = 166), clarithromycin (63.1%, n = 118), amoxicillin (39%, n = 73), and tetracycline (34.2%, n = 64), accordingly. Antibiotic resistance among H. pylori isolates was higher than expected, especially for amoxicillin and tetracycline, which is a concerning issue. Conclusion: Consequently, considering the central role of the antibiotic susceptibility profile in experimental therapy, it is recommended that determining the resistance pattern of the bacterium in all parts of Iran can lead to an effective treatment regimen. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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