Concentrations of blood styrene and neurobehavioral function among Gulf state residents in the U.S.

Objectives: To investigate relationships between blood styrene concentrations and neurobehavioral function among US Gulf State residents. Methods: Our study includes 328 Gulf state residents enrolled in the Gulf Long-term Follow-up Study with data on blood styrene concentrations (2012–2013) and neur...

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Publicado en:International Journal of Environmental Health Research Vol. 35; no. 10; pp. 2842 - 2855
Autores principales: Choi, Giehae, Rohlman, Diane S., Kwok, Richard K., Werder, Emily J., Lawrence, Kaitlyn G., Blair, Aaron, Miller, Aubrey K., Jackson II, W. Braxton, Sandler, Dale P., Engel, Lawrence S.
Formato: research tables/charts Journal Article
Publicado: Taylor & Francis Ltd Oct2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Oct2025
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      pub: Taylor & Francis Ltd
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        10.1080/09603123.2025.2464086
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        atl: Concentrations of blood styrene and neurobehavioral function among Gulf state residents in the U.S.
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        au:
          Choi, Giehae
          Rohlman, Diane S.
          Kwok, Richard K.
          Werder, Emily J.
          Lawrence, Kaitlyn G.
          Blair, Aaron
          Miller, Aubrey K.
          Jackson II, W. Braxton
          Sandler, Dale P.
          Engel, Lawrence S.
        affil: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
      sug:
        subj:
          Environmental Pollutants Blood
          Benzylidene Compounds Blood
          Environmental Exposure
          Neurobehavioral Manifestations
          Residence Characteristics United States by Region
          Human
          Funding Source
          Male
          Female
          Adult
          Middle Age
          Aged
          United States
          United States by Region
          Environmental Pollutants Poisoning
          Air Pollutants Analysis
          Cognition
          Psychomotor Performance
          Smoking
          Neuropsychological Tests
          Dose-Response Relationship
          Descriptive Statistics
          Data Analysis Software
          Confidence Intervals
          Sensitivity and Specificity
          Regression
          Mass Spectrometry
          Chromatography, Liquid
          Self Report
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Aged: 65+ years
          Male
          Female
      ab: Objectives: To investigate relationships between blood styrene concentrations and neurobehavioral function among US Gulf State residents. Methods: Our study includes 328 Gulf state residents enrolled in the Gulf Long-term Follow-up Study with data on blood styrene concentrations (2012–2013) and neurobehavioral test results (2014–2016, Behavioral Assessment and Research System and trail making test). We estimated the differences in test scores by blood styrene quartiles and explored effect measure modification by smoking. Results: Styrene was detected in 77% of participants (median: 0.06 ng/ml). We observed only weak associations and no apparent dose–response relationships between styrene levels and performance on any neurobehavioral tests, although some associations were more prominent in males. For some neurobehavioral tests, we observed modestly stronger associations among participants with higher cotinine levels (>15 ng/mL). Conclusion: We found limited support for an association between low-level blood styrene concentration and neurobehavioral test performance, although some associations were stronger among smokers.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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