Protective role of Cocos nucifera L. water on BPA-mediated oxidative stress and reproductive damage in male rats.
Bisphenol A (BPA) may impair male fertility by inducing oxidative stress in the testis, though its effects on spermatogenesis and sperm quality remain unclear. Conversely, Cocos nucifera L. (coconut) water, rich in antioxidants, effectively inhibits oxidative stress. The aim of the study is to evalu...
| Publicado en: | International Journal of Environmental Health Research Vol. 35; no. 11; pp. 3338 - 3351 |
|---|---|
| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Nov2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189081361&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189081361 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Nov2025 vid: 35 iid: 11 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 189081361 184070050 189081361 189081361 10.1080/09603123.2025.2484782 189081361 ppf: 3338 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Protective role of Cocos nucifera L. water on BPA-mediated oxidative stress and reproductive damage in male rats. aug: au: Shafie, Nur Farah Shafinaz Nurul Bashar, Nurul Kabir Abd Aziz, Nor Azlina Dasiman, Razif Hashim, Noor Hashida affil: Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia sug: subj: Coconut Therapeutic Use Fruit Juices Therapeutic Use Oxidative Stress Evaluation Phenols Adverse Effects Infertility Prevention and Control Animal Studies Rats Water Administration and Dosage Corn Oil Administration and Dosage Phenols Administration and Dosage Testis Analysis Epididymis Analysis Sperm Motility Evaluation Glutathione Analysis Malondialdehyde Analysis Histology Fluoroimmunoassay Fluorescent Antibody Technique Intubation, Gastrointestinal Biochemistry Evaluation In Vivo Studies Experimental Studies Enzyme-Linked Immunosorbent Assay Staining and Labeling Microscopy Software Data Analysis Software One-Way Analysis of Variance Post Hoc Analysis Descriptive Statistics Cell Culture Techniques ab: Bisphenol A (BPA) may impair male fertility by inducing oxidative stress in the testis, though its effects on spermatogenesis and sperm quality remain unclear. Conversely, Cocos nucifera L. (coconut) water, rich in antioxidants, effectively inhibits oxidative stress. The aim of the study is to evaluate the protective effect of Cocos nucifera L. water against BPA-mediated oxidative stress in male rats. Thirty Sprague-Dawley rats were divided into control (C) received distilled water (0.5 mL/day), vehicle (V) received corn oil (0.5 mL/day), Bisphenol A (B) (50 mg/kg/day), Cocos nucifera L. water (CW) (10 mL/kg/day) and Cocos nucifera L. water plus bisphenol A (CW+B) groups. The testes and epididymis were harvested on day 31 for oxidative stress analysis, histological examination, immunofluorescence assay, and sperm motility. BPA administration reduced glutathione levels, increased malondialdehyde levels, and caused histopathological changes in the testis. Additionally, the grayscale intensity of actin and tubulin immunofluorescence, along with sperm motility, significantly decreased in the B group (p < 0.001). However, these parameters were notably improved by the administration of coconut water in CW+B group (p < 0.001). Conclusively, this study suggests that coconut water enhances antioxidant defences and supports male reproductive health in rats, potentially preventing BPA-induced reproductive damage. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|