Causal pathways of plasma metabolites: unveiling metabolic associations in liver diseases.
Background: This study aimed to explore the causal relationships between 1,400 plasma metabolites and various chronic liver conditions, including liver fibrosis or cirrhosis, liver carcinoma, hepatic failure, and metabolic liver disorders. Methods: This study used a two-sample Mendelian randomizatio...
| Publicado en: | Nutrition & Metabolism Vol. 22; no. 1; pp. 1 - 11 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
BioMed Central
11/3/2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189086423&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189086423 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 11/3/2025 vid: 22 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 189086423 189086423 189086423 10.1186/s12986-025-01017-9 189086423 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Causal pathways of plasma metabolites: unveiling metabolic associations in liver diseases. aug: au: He, Xiaoxuan Ma, Yanfen Wu, Qian Feng, Jing Wang, Wei Zhao, Shan Wang, Xiaoqin affil: https://ror.org/02tbvhh96 Department of Clinical Laboratory, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, Shaanxi Province, China sug: subj: Liver Diseases Metabolism Plasma Metabolism Metabolites Metabolic Networks and Pathways Physiology Liver Cirrhosis Metabolism Liver Neoplasms Metabolism Liver Failure Metabolism Causality Human China Funding Source Descriptive Statistics Data Analysis Software Mendelian Randomization Mediation Analysis Fibrosis Risk Factors Liver Cirrhosis Risk Factors Risk Assessment Liver Diseases Risk Factors Carcinoma, Hepatocellular Disease Progression Biological Markers Blood ab: Background: This study aimed to explore the causal relationships between 1,400 plasma metabolites and various chronic liver conditions, including liver fibrosis or cirrhosis, liver carcinoma, hepatic failure, and metabolic liver disorders. Methods: This study used a two-sample Mendelian randomization (MR) method. Forward analysis focused on associations with four liver disease categories, whereas reverse analysis examined links with specific metabolites or ratios. Five MR methods were applied, primarily the inverse variance weighted (IVW) method. The IVW, Egger, and Weighted Median analyses showed p-values < 0.05 with positive directions, suggesting strong positive effects. The IVW analysis alone indicated a potential positive effect with p-value < 0.05. Sensitivity analyses ensured the results' robustness and validity. Results: In the forward causal analysis, we identified 252 potential causal associations, 13 of which were notably strong. Specifically, six plasma metabolites and metabolic ratios were found to increase the risk of fibrosis/cirrhosis, while the other three were associated with an increased likelihood of liver cancer. Additionally, three were positively correlated with metabolic liver disease risk and one was inversely related to liver failure risk. In contrast, reverse causal analysis revealed that fibrosis/cirrhosis was linked to ten plasma metabolites and metabolic ratios, whereas liver cancer was associated with three plasma metabolites and metabolic ratios. Conclusion: Our findings underscore the significant association between an elevated glucose-to-mannose ratio and a range of liver conditions, including fibrosis/cirrhosis, metabolic liver disease, and hepatoma, thereby highlighting the crucial role of glucose metabolism in liver disease. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|