Dietary amino acids and the odds of metabolic dysfunction-associated fatty liver disease (MAFLD) among overweight and obese children and adolescents: a principal component analysis approach.
Background: Given the limited understanding of how dietary amino acid intake affects metabolic dysfunction-associated fatty liver disease (MAFLD), we examined the potential relationship between dietary amino acid patterns and the odds of MAFLD in children and adolescents with overweight and obesity....
| Publicado en: | Nutrition & Metabolism Vol. 22; no. 1; pp. 1 - 16 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
BioMed Central
11/3/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189086424&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189086424 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 11/3/2025 vid: 22 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 189086424 189086424 189086424 10.1186/s12986-025-01023-x 189086424 ppf: 1 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Dietary amino acids and the odds of metabolic dysfunction-associated fatty liver disease (MAFLD) among overweight and obese children and adolescents: a principal component analysis approach. aug: au: Nikparast, Ali Mirzaei, Parmis Sohouli, Mohammad Hassan Tadayoni, Zeinab S. Behrad, Deniz Razavi, Maryam Rohani, Pejman Asghari, Golaleh affil: https://ror.org/034m2b326 Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition & Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Fatty Liver Epidemiology Fatty Liver Etiology Amino Acids Metabolism Amino Acids Administration and Dosage Pediatric Obesity Epidemiology Pediatric Obesity Complications Adolescent Nutrition Human Male Female Child Adolescence Adult Cross Sectional Studies Surveys Iran Child Nutrition Disorders Diagnosis Child Nutrition Disorders Epidemiology Factor Analysis Insulin Resistance Complications Body Mass Index Ultrasonography Methods Liver Diseases Diagnosis Liver Diseases Epidemiology Dietary Proteins Energy Intake Physical Activity Puberty Triglycerides Arginine Logistic Regression Descriptive Statistics Confidence Intervals Odds Ratio Data Analysis Software Questionnaires Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Male Female ab: Background: Given the limited understanding of how dietary amino acid intake affects metabolic dysfunction-associated fatty liver disease (MAFLD), we examined the potential relationship between dietary amino acid patterns and the odds of MAFLD in children and adolescents with overweight and obesity. Methods: This cross-sectional study was conducted on participants aged 6 to 18 years with a WHO body mass index (BMI)-for-age z-score ≥ 1. MAFLD diagnosis followed established consensus definitions. Principal component factor analyses were conducted based on eighteen amino acids. Logistic regression models, adjusted for potential confounders, were used to estimate the odds of MAFLD across amino acid profile score quartiles. Results: A total of 505 (52.9% boys) with mean ± SD age and BMI-for-age-Z-score of 10.0 ± 2.3 and 2.70 ± 1.01, respectively, were enrolled. Three major amino acid profiles were characterized: (1) higher loads by branched chain, lysine, tyrosine, threonine, methionine, histidine, alanine, and aspartic acid; (2) higher loads of proline, serine, glutamic acid, and phenylalanine; (3) higher loads of tryptophan, arginine, glycine, and cysteine. After adjusting for all potential confounders, participants in the highest quartile of the first amino acid profile tended to be associated with increased odds of MAFLD (OR:2.14; 95%CI:0.97–4.77). There was no significant association for the second and third profiles. Conclusions: These novel data suggest that the amino acid composition of an individual's diet may modify their odds of MAFLD. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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