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Effect of sevoflurane on hemodynamic response during cardiopulmonary bypass in cardiac surgery patients: A randomized controlled trial.

Introduction: Sevoflurane has little effect on hemodynamics and has been shown to have a hemodynamic stabilizing effect in the pre- and post-cardiopulmonary bypass (CPB) period in patients undergoing cardiac surgery. However, clinical data on the effect of sevoflurane on the hemodynamic response dur...

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Published in:Journal of Cardiovascular & Thoracic Research Vol. 17; no. 3; pp. 159 - 167
Main Authors: Lam, Vu Thanh, Ly, Nguyen Minh
Format: research tables/charts randomized controlled trial Journal Article
Published: Tabriz University of Medical Sciences Sep2025
Online Access:View this record in EBSCOhost
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      dt: Sep2025
      vid: 17
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      pub: Tabriz University of Medical Sciences
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        10.34172/jcvtr.025.33239
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        atl: Effect of sevoflurane on hemodynamic response during cardiopulmonary bypass in cardiac surgery patients: A randomized controlled trial.
      aug:
        au:
          Lam, Vu Thanh
          Ly, Nguyen Minh
        affil: Department of Anesthesiology and Pain Management, Vinmec Times City International Hospital, Hanoi, Vietnam
      sug:
        subj:
          Cardiopulmonary Bypass Methods
          Surgery, Cardiovascular Methods
          Sevoflurane Therapeutic Use
          Drug Efficacy Evaluation
          Hemodynamics Drug Effects
          Human
          Vietnam
          Male
          Female
          Adult
          Middle Age
          Randomized Controlled Trials
          Random Assignment
          Propofol Therapeutic Use
          Vasoconstrictor Agents Therapeutic Use
          Postoperative Complications
          Morbidity
          Hospital Mortality
          Oxygen Saturation
          Stroke Volume
          Arterial Pressure
          Microcirculation
          Descriptive Statistics
          Chi Square Test
          Fisher's Exact Test
          T-Tests
          Mann-Whitney U Test
          Data Analysis Software
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Male
          Female
      ab: Introduction: Sevoflurane has little effect on hemodynamics and has been shown to have a hemodynamic stabilizing effect in the pre- and post-cardiopulmonary bypass (CPB) period in patients undergoing cardiac surgery. However, clinical data on the effect of sevoflurane on the hemodynamic response during CPB in patients undergoing cardiac surgery are lacking. This study investigated whether the hemodynamic stabilizing effect of sevoflurane is demonstrated during CPB time in cardiac surgery patients. Methods: Fifty-five patients undergoing cardiac surgery under CPB were randomly assigned to anesthesia with sevoflurane (intervention group) or propofol (control group) during CPB. The primary outcomes were changes in hemodynamic parameters and the need for inotropes and vasopressors during CPB. Secondary outcomes were morbidity and mortality within 30 days after surgery. Results: The mean arterial pressure (MAP) at 5 minutes after heartbeat recovery and the end of CPB as well as central venous oxygen saturation (ScvO2) at 5 minutes after heartbeat recovery and cardiac index (CI) at the end of CPB of group S-CPB (intervention group) were higher than those of group P-CPB (control group). In addition, the proportion of patients using dobutamine and noradrenaline during CPB was also lower in group S-CPB. Conclusion: In conclusion, in patients undergoing cardiac surgery under CPB, the use of sevoflurane for anesthesia during CPB results in hemodynamic stability with less need for inotropes and vasopressors during CPB but morbidity and mortality within 30 days after surgery were not significantly different when compared with the control group.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        randomized controlled trial
        Journal Article
      ougenre: Article
    language: English
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