Identifying tophaceous gout in foot ulcers using ulcer debris microscopy in Type 2 diabetes.
Gout is frequently underdiagnosed in patients with diabetes. As a chronic disease characterised by urate deposition, gout can lead to the formation of tophi in the feet, which may ulcerate. However, the prevalence of tophaceous gout in patients with diabetes and foot ulcers has not been previously s...
| Publicado en: | Journal of Wound Management Vol. 26; no. 3; pp. 175 - 182 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Cambridge Publishing
Nov2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189092394&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189092394 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 27885771 MZEQ jtl: Journal of Wound Management issn: 27885771 maglogo: N pubinfo: dt: Nov2025 vid: 26 iid: 3 pid: 66266 pub: Cambridge Publishing artinfo: ui: 189092394 189092394 189092394 10.35279/jowm2025.26.03.08 189092394 ppf: 175 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Identifying tophaceous gout in foot ulcers using ulcer debris microscopy in Type 2 diabetes. aug: au: </strong>, <strong>Author(s) Rasmussen, Claus Larsen, Jesper Walther Holm, Peter CW Bisgaard, Trine Stenbak Søbye, Marie-Louise Lund Jepsen, Søren Terpager Nielsen, Gunnar L Jurik, Anne Grethe affil: Søren Terpager Jepsen 6, Gunnar L Nielsen 5,7, Anne Grethe Jurik 4, 1 Department of Rheumatology, North Denmark Regional Hospital, Hjørring, Denmark sug: subj: Gout Diagnosis Foot Ulcer Microscopy Diabetes Mellitus, Type 2 Denmark Human Male Female Middle Age Aged Diabetic Patients Pilot Studies Prospective Studies Quality Improvement Chi Square Test Fisher's Exact Test Mann-Whitney U Test Descriptive Statistics Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Gout is frequently underdiagnosed in patients with diabetes. As a chronic disease characterised by urate deposition, gout can lead to the formation of tophi in the feet, which may ulcerate. However, the prevalence of tophaceous gout in patients with diabetes and foot ulcers has not been previously studied. This study explored the feasibility of sampling foot ulcer debris for polarised light microscopy to detect birefringent urate crystals and identify cases of gout in patients with diabetes. Among 36 ulcer debris samples examined, urate crystals were identified in five cases (14%) strongly suggesting previously unrecognised gout. Radiographic findings further supported tophaceous gout as the primary cause of these foot ulcers. These findings indicate that unrecognised tophaceous gout may be relatively common among patients with Type 2 diabetes and foot ulcers. However, selection bias may have led to an overestimation of prevalence, while insufficient or contaminated samples may have resulted in an underestimation. Further refinement of sampling and examination techniques--ideally supplemented by imaging prior to ulcer treatment --is needed to improve the detection of all cases with urate crystals and to ensure that negative findings truly reflect the absence of gout rather than technical limitations. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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