Gender-related differences in cognitive performance and cognitive stimulation efficacy in subjects with Parkinson's disease and mild cognitive impairment.
Background: Gender-related differences in cognitive performances of subjects with Parkinson's Disease and mild cognitive impairment (MCI-PD) have been recently investigated in a few studies, yielding heterogeneous results. Cognitive stimulation (CS) is a promising non-pharmacological treatment in MC...
| Published in: | Frontiers in Aging Neuroscience pp. 1 - 12 |
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| Main Authors: | , , , , , , , , |
| Format: | research tables/charts randomized controlled trial Journal Article |
| Published: |
Frontiers Media S.A.
2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189104465&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189104465 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 2025 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 189104465 189104465 189104465 10.3389/fnagi.2025.1672084 189104465 ppf: 1 ppct: 11 formats: tig: atl: Gender-related differences in cognitive performance and cognitive stimulation efficacy in subjects with Parkinson's disease and mild cognitive impairment. aug: au: Iaccino, Noemi Buonocore, Jolanda Torchia, Giusi Curcio, Francesca Pirrotta, Fabio M. Contrada, Marianna Pignolo, Loris Gambardella, Antonio Arabia, Gennarina affil: Department of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy sug: subj: Parkinson Disease Psychosocial Factors Cognition Disorders Therapy Sex Factors Cognition Evaluation Cognitive Therapy Methods Treatment Outcomes Evaluation Funding Source Human Male Female Middle Age Aged Aged, 80 and Over Randomized Controlled Trials Random Assignment Academic Medical Centers Italy Neuropsychological Tests Activities of Daily Living Short Form-36 Health Survey (SF-36) Scales Questionnaires Data Analysis Software Unpaired T-Tests Mann-Whitney U Test Wilcoxon Signed Rank Test Multivariate Analysis of Covariance Multiple Linear Regression Descriptive Statistics Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Background: Gender-related differences in cognitive performances of subjects with Parkinson's Disease and mild cognitive impairment (MCI-PD) have been recently investigated in a few studies, yielding heterogeneous results. Cognitive stimulation (CS) is a promising non-pharmacological treatment in MCI-PD subjects and no data regarding gender differences in its efficacy are available yet. The aim of this study was to investigate gender-related differences in cognitive functions and CS efficacy in subjects with MCI-PD. Methods: Forty-five MCI-PD subjects (30 men, 15 women) were randomized to a 4-week CS program, delivered either via tele-rehabilitation (TR) or with a conventional in-person approach. A broad clinical and neuropsychological assessment, including the Cognitive Reserve Index questionnaire, was conducted at baseline (T1), post-treatment (T2), and at 6-month follow-up (T3). Results: At baseline, women showed a lower cognitive reserve (CR) compared to men (p = 0.039). After adjusting for CR, women performed worse than men in global cognition, attention, and visuospatial abilities. After CS treatment, men demonstrated significant improvements in global cognition, language, executive functions, working memory, visuospatial abilities, attention, and trait anxiety (p < 0.05). Women showed significant improvements in global cognition (MoCA, p = 0.036) and mood (BDI, p = 0.021). Men outperformed women in several domains, both in TR and in-person rehabilitation groups. Regression models revealed a stronger modulatory effect of CR in global cognition, attention, memory, and language, in women. After a 6-month treatment discontinuation, cognitive performance measures significantly worsened in all subjects, regardless of gender. Conclusion: Our study showed gender-related differences both in cognitive functions and in efficacy of CS in subjects with MCI-PD, also highlighting the role of cognitive reserve. These findings support the relevance of developing gender-tailored cognitive rehabilitation strategies to enhance treatment outcomes and improve the quality of life for individuals with MCI-PD. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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