Serum interleukin-36γ levels in children with allergic rhinitis: a cross-sectional study.
Objectives: This study aimed to investigate whether serum Interleukin 36 gamma (IL-36γ) levels in pediatric allergic rhinitis patients correlate with disease severity (mild, moderate, severe) and duration (intermittent, persistent). Additionally, we assessed the potential of IL-36γ as a biomarker an...
| Publicado en: | Colombia Medica Vol. 56; no. 2; pp. 1 - 14 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
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Universidad del Valle
2025
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=189110451&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 189110451 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 01208322 165D jtl: Colombia Medica issn: 01208322 maglogo: N pubinfo: dt: 2025 vid: 56 iid: 2 pid: 19876 pub: Universidad del Valle artinfo: ui: 189110451 10.25100/cm.v56i2.6690 ppf: 1 ppct: 13 formats: fmt: @attributes: type: P size: 2.4MB tig: atl: Serum interleukin-36γ levels in children with allergic rhinitis: a cross-sectional study. aug: au: Aydenizoz, Dogukan Tarik, Selcuk Omer Eyigor, Hulya Yasar, Ellidag Hamit Filiz, Serkan Keles, Sennur affil: University of Health Sciences, Antalya Training and Research Hospital, Department of Otorhinolaryngology, Antalya, Turkey. University of Health Sciences, Antalya Training and Research Hospital, Department of Biochemistry, Antalya, Turkey. University of Health Sciences, Antalya Training and Research Hospital, Department of Pediatric Allergy and Immunology, Antalya, Turkey. su: Cross-sectional method Statistical correlation Pearson correlation (Statistics) Disease duration T-test (Statistics) Scientific observation Sample size (Statistics) Enzyme-linked immunosorbent assay Immunoglobulins Sex distribution Severity of illness index Chi-squared test Mann Whitney U Test Descriptive statistics Rhinitis Data analysis software Interleukins Eosinophils Evaluation Children sug: subj: Cross-sectional method Statistical correlation Pearson correlation (Statistics) Disease duration T-test (Statistics) Scientific observation Sample size (Statistics) Enzyme-linked immunosorbent assay Immunoglobulins Sex distribution Severity of illness index Chi-squared test Mann Whitney U Test Descriptive statistics Rhinitis Data analysis software Interleukins Eosinophils Evaluation Children keyword: Allergic rhinitis cytokines disease severity IL-36γ pediatric allergy alergia pediátrica citocinas Rinitis alérgica ab: Objectives: This study aimed to investigate whether serum Interleukin 36 gamma (IL-36γ) levels in pediatric allergic rhinitis patients correlate with disease severity (mild, moderate, severe) and duration (intermittent, persistent). Additionally, we assessed the potential of IL-36γ as a biomarker and its role in disease pathogenesis to inform future treatment strategies. Methods: In this cross-sectional observational study, pediatric allergic rhinitis patients from outpatient clinics were compared with healthy controls. Serum IL-36γ levels were measured from blood samples and analyzed across subgroups based on disease severity and duration. Results: Fifty patients with allergic rhinitis and forty controls were included. IL-36γ levels were higher in the patient group with borderline significance (p= 0.050). Female patients had significantly higher IL-36γ levels than male controls (p= 0.044). Conclusions: This is the first study to evaluate IL-36γ levels in pediatric allergic rhinitis. Although the difference between groups showed borderline significance, larger studies may confirm these findings. The observed gender-related difference suggests IL-36γ could be a potential biomarker. Additionally, a significant negative correlation with total IgE and a nonsignificant negative correlation with eosinophil counts were noted. Objetivos: Investigar si los niveles séricos de interleucina 36 gamma (IL-36γ) en pacientes pediátricos con rinitis alérgica se correlacionan con la gravedad de la enfermedad (leve, moderada, grave) y su duración (intermitente, persistente). Además, evaluamos el potencial de la IL-36γ como biomarcador y su papel en la patogénesis de la enfermedad para implementar futuras estrategias de tratamiento. Métodos: En este estudio observacional transversal, se comparó a pacientes pediátricos con rinitis alérgica de clínicas ambulatorias con controles sanos. Se midieron los niveles séricos de IL-36γ a partir de muestras de sangre y se analizaron en subgrupos según la gravedad y la duración de la enfermedad. Resultados: Se incluyeron 50 pacientes con rinitis alérgica y 40 controles. Los niveles de IL-36γ fueron más altos en el grupo de pacientes, con una significación límite (p= 0.050). Las pacientes mujeres tenían niveles de IL-36γ significativamente más altos que los controles masculinos (p= 0.044). Conclusiones: Este es el primer estudio que evalúa los niveles de IL-36γ en la rinitis alérgica pediátrica. Aunque la diferencia entre los grupos mostró una significación límite, estudios más amplios podrían confirmar estos hallazgos. La diferencia observada en función del sexo sugiere que la IL-36γ podría ser un posible biomarcador. Además, se observó una correlación negativa significativa con la IgE total y una correlación negativa no significativa con el recuento de eosinófilos. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Colombia Medica is the property of Universidad del Valle and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Colombia Medica holder: Universidad del Valle dt: @attributes: year: 2025 holdings: @attributes: islocal: N |
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