[18F]Fluorocholine PET/MRI and [18F]Fluorocholine PET/CT as first- and second-line imaging in primary hyperparathyroidism – who takes the lead?
Purpose: Accurate preoperative localization of hyperfunctioning parathyroid glands is essential for enabling a focused surgical approach in patients with primary hyperparathyroidism (pHPT). Our study aims to determine the diagnostic value of 18F-fluorocholine positron emission tomography/magnetic re...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 52; no. 13; pp. 5165 - 5175 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189136484&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189136484 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Nov2025 vid: 52 iid: 13 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 189136484 185518738 10.1007/s00259-025-07373-1 189136484 ppf: 5165 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: [18F]Fluorocholine PET/MRI and [18F]Fluorocholine PET/CT as first- and second-line imaging in primary hyperparathyroidism – who takes the lead? aug: au: Petranović Ovčariček, Petra Schaab, Jan Beintner-Skawran, Stephan Maurer, Alexander Rupp, Niels J. Ikenberg, Kristian Morand, Grégoire B. Mueller, Simon A. Vetter, Diana Liberini, Virginia Giovanella, Luca Huellner, Martin W. affil: https://ror.org/00r9vb833 Department of Oncology and Nuclear Medicine, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia sug: ab: Purpose: Accurate preoperative localization of hyperfunctioning parathyroid glands is essential for enabling a focused surgical approach in patients with primary hyperparathyroidism (pHPT). Our study aims to determine the diagnostic value of 18F-fluorocholine positron emission tomography/magnetic resonance imaging ([18F]FCH PET/MRI) and [18F]FCH PET/computed tomography (PET/CT) in identifying parathyroid adenomas. Methods: We conducted a retrospective study to assess the diagnostic accuracy of [18F]FCH PET/MRI and [18F]FCH PET/CT as first- and second-line methods for detecting parathyroid adenomas in patients with pHPT. The primary endpoints included patient-based sensitivity, specificity, and positive predictive value (PPV), with intraoperative surgical localization and histopathological analysis serving as reference, i.e., gold standard. Results: The study included 322 patients. A total of 264 patients underwent [18F]FCH PET/MRI, thereof 155 and 109 as a second- and first-line method, respectively. [18F]FCH PET/CT was performed in 58 patients, thereof 44 and 14 in a second- and first-line setting, respectively. Total sensitivity, specificity, PPV, negative predictive value (NPV), and diagnostic accuracy of [18F]FCH PET/MRI were 0.967, 0.818, 0.983, 0.692, and 0.955, respectively, while the same parameters for [18F]FCH PET/CT were 0.980, 0.875, 0.980, 0.875, and 0.966, respectively (all p > 0.05). There was also no difference between the two methods in the first- or second-line imaging scenarios. Conclusion: Both [18F]FCH PET/MRI and [18F]FCH PET/CT are highly accurate imaging modalities for localizing parathyroid adenomas in both first- and second-line settings. They can be regarded as "top-scoring" or "one-stop-shop" techniques for preoperative assessment. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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