Brain morphology in adolescent girls with first-onset anorexia nervosa.
This study aimed to assess whether a young, first-onset cohort of girls with anorexia nervosa (AN) demonstrate similar findings of reduced gray and white matter volume reductions as reported in older women with chronic AN. We compared adolescents and young adults with first-onset AN to typically dev...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 10; pp. 3071 - 3082 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189168592&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189168592 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Oct2025 vid: 34 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 189168592 184669325 189168592 189168592 10.1007/s00787-025-02715-8 189168592 ppf: 3071 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Brain morphology in adolescent girls with first-onset anorexia nervosa. aug: au: Kovoor, Janneke S. P. Bracké, Katrien F.M. White, Tonya Dieleman, Gwen C. affil: https://ror.org/047afsm11 Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands sug: subj: Age Factors Women Anorexia Nervosa Gray Matter Anatomy and Histology White Matter Anatomy and Histology Human Anorexia Nervosa Symptoms Brain Magnetic Resonance Imaging Methods Body Mass Index Evaluation Brain Anatomy and Histology Linear Regression Thinness Questionnaires Malnutrition Complications Data Analysis Software Neurodevelopment Prospective Studies Psychological Tests Female Child Adolescence Adult Clinical Assessment Tools Funding Source Cerebral Cortex Anatomy and Histology Child: 6-12 years Adolescent: 13-18 years Adult: 19-44 years Female ab: This study aimed to assess whether a young, first-onset cohort of girls with anorexia nervosa (AN) demonstrate similar findings of reduced gray and white matter volume reductions as reported in older women with chronic AN. We compared adolescents and young adults with first-onset AN to typically developing (TD) girls and investigated associations between brain volume measures and clinical symptoms. Whole-brain T1-weighted structural imaging was performed in 58 young persons with AN and 63 age, sex-, and education-matched TD participants. Participants with AN were further divided into underweight (undAN) and restored weight (restAN) groups based on body mass index length/weight standard deviation score (BMI-SDS). Eating disorder symptoms were measured by the Eating Disorder Examination (EDE) and the Eating Disorder Inventory-3 (EDI-3). Differences in brain volume measures were analyzed using separate linear regression analyses. Within the AN group, associations between brain volumes, BMI-SDS, and EDE/EDI-3 scores were analyzed. The undAN group showed significant reductions in total and cortical gray matter volumes compared to the TD group, primarily in the frontal and parietal cortices. No significant associations were found between brain volume and BMI-SDS or EDE/EDI-3 scores. Frontal and parietal cortices in adolescents and young adults with undAN are particularly affected by malnutrition, showing gray matter volume reductions even in early stages of AN. Longitudinal studies are needed to explore the effects of malnutrition on brain development and its association with clinical features of AN over time. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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