Abnormal alterations in neurodevelopment in preterm children with very low birth weight during the adolescence.
Background: Preterm infants with very low birth weight are at high risk for long-term neurocognitive deficits. However, whether these neurocognitive deficits are improved or worsened in adolescence remains unclear. Methods: We took advantage of the large sample from the Adolescent Brain Cognitive De...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 10; pp. 3137 - 3150 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189168600&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189168600 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Oct2025 vid: 34 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 189168600 184991778 189168600 189168600 10.1007/s00787-025-02724-7 189168600 ppf: 3137 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Abnormal alterations in neurodevelopment in preterm children with very low birth weight during the adolescence. aug: au: Ji, Weibin Li, Guanya Hu, Yang Zhang, Wenchao Li, Jingyuan Li, Yuefeng Gao, Xinbo Manza, Peter Volkow, Nora D. Wang, Gene-Jack Zhang, Yi affil: https://ror.org/05s92vm98 Center for Brain Imaging, School of Life Science and Technology, Engineering Research Center of Molecular and Neuro Imaging, Xidian University, Ministry of Education, 710126, Xi'an, Shaanxi, China sug: subj: Cognition Disorders Risk Factors Neurodevelopment Behavioral Changes Evaluation Adolescent Behavior Evaluation Neuroradiography Infant, Premature Infant, Low Birth Weight Risk Assessment Human Child Adolescence Male Female United States Funding Source Prospective Studies Multicenter Studies Correlational Studies Brain Physiology Cognition Evaluation Mental Health Puberty Brain Cortical Thickness Frontal Lobe Temporal Lobe Occipital Lobe Insular Cortex Thalamus Cerebellum Prefrontal Cortex Psychopathology Sociodemographic Factors Magnetic Resonance Imaging Scales Data Analysis Software Post Hoc Analysis Checklists Child: 6-12 years Adolescent: 13-18 years Male Female ab: Background: Preterm infants with very low birth weight are at high risk for long-term neurocognitive deficits. However, whether these neurocognitive deficits are improved or worsened in adolescence remains unclear. Methods: We took advantage of the large sample from the Adolescent Brain Cognitive Development dataset to investigate alterations in brain structure, behavior, including cognitive function and mental health symptoms, and in puberty among preterm children with very low/normal birth weight (Pre_VLBW/Pre_NBW) and full-term children with normal birth weight (Con_NBW) from baseline to 2-year follow-up. Results: Pre_VLBW children relative to the other two groups had higher cortical thickness, lower cortical area and cortical/subcortical volumes in large portions of frontal cortex, temporal and occipital gyrus, insula, thalamus, and cerebellum; and attenuated fiber tract volumes in the fornix and foreceps major at baseline. Pre_VLBW children for their baseline measures also had lower cognitive function, higher pubertal levels and psychopathological risk. Furthermore, there were significant interaction effects on increased adrenarche score and cortical and subcortical volumes in medial orbitofrontal cortex (mOFC) and thalamus from baseline to 2-year follow-up. Pre_VLBW individuals showed higher adrenarche scores and lower volumes in the mOFC and thalamus than the other two groups at 2-year follow-up, but not at baseline. These brain structural changes showed associations with pubertal development levels, psychopathological risk and cognitive deficits. Conclusion: These findings support a view that preterm children with VLBW showed distinctive developmental alterations during adolescence, which potentially lead to long-lasting deviations in various brain regions and might be associated with behavioral problems and neurocognitive deficits. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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