Age-related differences in psychopathology within sex chromosome trisomies.
Sex chromosome trisomies (SCTs) are a group of genetic disorders characterized by presence of a supernumerary sex chromosome, resulting in karyotypes other than XX or XY. These include XXX (Trisomy X), XXY (Klinefelter syndrome), and XYY (Jacobs syndrome). SCTs have been linked to increased risk for...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 10; pp. 3275 - 3285 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Oct2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189168617&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189168617 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Oct2025 vid: 34 iid: 10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 189168617 185347495 189168617 189168617 10.1007/s00787-025-02743-4 189168617 ppf: 3275 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Age-related differences in psychopathology within sex chromosome trisomies. aug: au: Roybal, Melissa R. Liu, Siyuan Larsen, Isabella G. Wass, Anastasia Schaffer, Lukas Ajumobi, Tiffany Whitman, Ethan T. Warling, Allysa Clasen, Liv Blumenthal, Jonathan Rau, Srishti Raznahan, Armin affil: https://ror.org/04xeg9z08 Section on Developmental Neurogenomics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA sug: subj: Age Factors Psychopathology Sex Chromosome Disorders Psychosocial Factors Chromosome Aberrations Familial and Genetic Child Behavior Disorders Adolescent Behavior Human Male Female Funding Source Cross Sectional Studies Nonexperimental Studies Intelligence Tests Socioeconomic Factors United States Checklists Post Hoc Analysis Child Adolescence Descriptive Statistics Data Analysis Software Inferential Statistics Surveys Child Behavior Checklist Scales Child: 6-12 years Adolescent: 13-18 years Male Female ab: Sex chromosome trisomies (SCTs) are a group of genetic disorders characterized by presence of a supernumerary sex chromosome, resulting in karyotypes other than XX or XY. These include XXX (Trisomy X), XXY (Klinefelter syndrome), and XYY (Jacobs syndrome). SCTs have been linked to increased risk for psychopathology; however, this relationship warrants additional research. Specifically, little is known regarding potential age-related variation in risk for psychopathology and how this may differ across karyotypes and subdomains of psychopathology. This has important implications for psychoeducation (e.g., informing carriers of the likelihood for varying manifestations with age), personalized care, and research into the mechanisms of pathophysiology. Thus, we used the Child Behavior Checklist (CBCL) to estimate age-related variation in psychopathology in a large cross-sectional sample of SCT carriers (n = 201) and euploidic controls (n = 304) spanning the age range of 5–18 years. We found that elevations of psychopathology in carriers were significantly associated with age in a manner that varied as a combined function of the karyotype and CBCL scale being considered. Post hoc tests revealed there is a uniquely pronounced age-associated increase in severity of social problems in the XYY karyotype, alongside a lack of statistical evidence for age-related variation in the severity of psychopathology for other CBCL domains and SCT karyotypes. Our findings are relevant for advancing the personalization of clinical assessment and monitoring in SCT carriers. They also highlight potential windows of dynamic risk emergence for closer clinical and biological study, as well as opportunities to provide intervention to mitigate future risk. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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