Synhesis, anti-inflammatory and analgesic activity of the supramolecular complex of 3-EPI-2-deoxyecdysone and prospects for its medical application.
3α,14α,22R,25-Tetrahydroxy-5β(H)-cholest-7-en-6-one, or 3-epi-2-deoxyecdysone, was isolated from the aerial parts of the Kazakhstani plant Acanthophyllum gypsophiloides Regel. Quantum-chemical calculations of the molecules using density functional theory (DFT) and ONIOM (a hybrid method combining qu...
| Publicado en: | Fitoterapia Vol. 187 |
|---|---|
| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Elsevier B.V.
Dec2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189207167&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189207167 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0367326X JF4 jtl: Fitoterapia issn: 0367326X maglogo: N pubinfo: dt: Dec2025 vid: 187 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 189207167 189207167 189207167 10.1016/j.fitote.2025.106952 189207167 ppct: 1 formats: tig: atl: Synhesis, anti-inflammatory and analgesic activity of the supramolecular complex of 3-EPI-2-deoxyecdysone and prospects for its medical application. aug: au: Tuleuov, Borash Abulyaissova, Lyazzat Temirgaziyev, Bakhtiyar Kassymova, Maral Almagambetov, Kairtai Melsov, Maxat Kozhanova, Aizhan Drasar, Pavel Adekenov, Sergazy affil: Research and Production Center "Phytochemistry", Gazaliyev St. 4, Karaganda 100009, Kazakhstan sug: subj: Plant Extracts Pharmacodynamics Plants, Medicinal Pharmacodynamics Antiinflammatory Agents Pharmacodynamics Analgesics Pharmacodynamics Plant Extracts Therapeutic Use Steroids Therapeutic Use Antiinflammatory Agents Therapeutic Use Analgesics Therapeutic Use Plant Components, Aerial Analysis Inflammation Drug Therapy Analgesia Steroids Pharmacodynamics Magnetic Resonance Spectroscopy Treatment Outcomes Kazakhstan Drug Stability ab: 3α,14α,22R,25-Tetrahydroxy-5β(H)-cholest-7-en-6-one, or 3-epi-2-deoxyecdysone, was isolated from the aerial parts of the Kazakhstani plant Acanthophyllum gypsophiloides Regel. Quantum-chemical calculations of the molecules using density functional theory (DFT) and ONIOM (a hybrid method combining quantum and molecular mechanics) were carried out to investigate the stability and properties of the inclusion complex of 3-epi-2-deoxyecdysone with β-cyclodextrin. Directed synthesis was performed, and supramolecular complex formation of the phytoecdysteroid with β-cyclodextrin was studied by NMR spectroscopy. The analgesic and anti-inflammatory activities of the resulting complex were evaluated. [Display omitted] pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|