Relationship between spleen volume and diameter for assessment of response to treatment on CT in patients with hematologic malignancies enrolled in clinical trials.
Purpose: Investigate spleen diameter (d) and volume (v) relationship in patients with hematologic malignancies (HM) by determining volumetric thresholds that best correlate to established diameter thresholds for assessing response to treatment. Exploratorily, interrogate the impact of volumetric mea...
| Published in: | Abdominal Radiology Vol. 50; no. 12; pp. 5799 - 5810 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Dec2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189212010&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189212010 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Dec2025 vid: 50 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 189212010 185519278 10.1007/s00261-025-05030-7 189212010 ppf: 5799 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Relationship between spleen volume and diameter for assessment of response to treatment on CT in patients with hematologic malignancies enrolled in clinical trials. aug: au: Hasenstab, Kyle A. Lu, Jie Leong, Lambert T. Bossard, Emily Pylarinou-Sinclair, Evye Devi, Karthika Cunha, Guilherme M. affil: https://ror.org/0264fdx42 Department of Mathematics and Statistics, San Diego State University, San Diego, USA sug: ab: Purpose: Investigate spleen diameter (d) and volume (v) relationship in patients with hematologic malignancies (HM) by determining volumetric thresholds that best correlate to established diameter thresholds for assessing response to treatment. Exploratorily, interrogate the impact of volumetric measurements in response categories and as a predictor of response. Methods: Secondary analysis of prospectively collected clinical trial data of 382 patients with HM. Spleen diameters were computed following Lugano criteria and volumes using deep learning segmentation. d and v relationship was estimated using power regression model, volumetric thresholds () for treatment response estimated; threshold search to determine percentual change ( and minimum volumetric increase () that maximize agreement with Lugano criteria performed. Spleen diameter and volume predictive performance for clinical response investigated using random forest model. Results: describes the relationship between spleen diameter and volume. for splenomegaly was 546 cm³. , , and for assessing response resulting in highest agreement with Lugano criteria were 570 cm3, 73%, and 170 cm3, respectively. Predictive performance for response between diameter and volume were not significantly different (P=0.78). Conclusion: This study provides empirical spleen volume threshold and percentual changes that best correlate with diameter thresholds, i.e., Lugano criteria, for assessment of response to treatment in patients with HM. In our dataset use of spleen volumetric thresholds versus diameter thresholds resulted in similar response assessment categories and did not signal differences in predictive values for response. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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