Association of Host Interleukin 8 Promoter Polymorphism with Helicobacter pylori induced Gastritis among Bangladeshi People.
Background: Helicobacter pylori induced gastritis involves dense mucosal granulocyte infiltration, driven by pro-inflammatory cytokines like interleukin-8 (IL-8), with cytokine gene polymorphisms influencing secretion levels. Objective: The study investigated the association of IL-8–251 A/T polymorp...
| Publicado en: | Bangladesh Journal of Infectious Diseases Vol. 12; no. 1; pp. 85 - 93 |
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| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Bangladesh Infection Research Association
Jun2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189221444&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189221444 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 24114820 MI0S jtl: Bangladesh Journal of Infectious Diseases issn: 24114820 maglogo: N pubinfo: dt: Jun2025 vid: 12 iid: 1 pid: 57650 pub: Bangladesh Infection Research Association artinfo: ui: 189221444 189221444 189221444 10.3329/bjid.v12i1.84053 189221444 ppf: 85 ppct: 8 formats: tig: atl: Association of Host Interleukin 8 Promoter Polymorphism with Helicobacter pylori induced Gastritis among Bangladeshi People. aug: au: Saha, Ritu Ahmed, Sharmeen Mahtab Uddin, Bhuiyan Mohammad Rahman, Mayisha Yusuf, Abdullah affil: Associate Professor, Department of Microbiology, Bashundhara Ad-din medical College, Dhaka, Bangladesh. sug: subj: Helicobacter Infections Complications Gastritis Risk Factors Duodenal Diseases Risk Factors Severity of Illness Risk Assessment Gastritis Immunology Duodenal Diseases Immunology Gastritis Familial and Genetic Duodenal Diseases Familial and Genetic Interleukins Polymorphism, Genetic Human Bangladesh Genetic Risk Score Prospective Studies Nonexperimental Studies Outpatients Helicobacter Infections Diagnosis Rapid Diagnostic Tests Polymerase Chain Reaction Gastritis Classification Data Analysis Software Descriptive Statistics Chi Square Test Fisher's Exact Test Logistic Regression Odds Ratio Confidence Intervals Male Female Adult Middle Age Helicobacter Infections Immunology Helicobacter Infections Familial and Genetic Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Helicobacter pylori induced gastritis involves dense mucosal granulocyte infiltration, driven by pro-inflammatory cytokines like interleukin-8 (IL-8), with cytokine gene polymorphisms influencing secretion levels. Objective: The study investigated the association of IL-8–251 A/T polymorphism (Three genotypes: A/A, A/T, T/T) with gastroduodenal diseases in Helicobacter pylori infected patients. Methodology: This was a prospective observational study that recruited gastritis patients who underwent upper gastrointestinal endoscopic examinations at the outpatient department of Gastroenterology at Bangladesh Medical University, Dhaka, Bangladesh (Former: Bangabandhu Sheikh Mujib Medical University (BSMMU)) and Dhaka Medical College Hospital in Dhaka, Bangladesh, from 2015 to 2020. Patients who received Helicobacter pylori eradication treatment in the previous 2 months, elderly individuals aged more than 65 years and those who had severe medical or surgical illnesses or had used proton pump inhibitors, nonsteroidal anti-inflammatory drugs, colloidal bismuth compounds, or antibiotics within 4 weeks of enrollment were excluded from the study. The Helicobacter pylori infection was identified using a rapid urease test, PCR of the ureC gene, and histological examination. Grading of gastritis was diagnosed through histopathological analysis and was graded as normal gastric mucosa (Grade - 0, I), Chronic gastritis (Grade-II), and Chronic active gastritis (Grade-III). Interleukin-8 (IL-8) gene polymorphism at the -251 position was detected by Polymerase Chain Reaction restriction fragment length polymorphism. Results: The frequencies of IL-8 T/A, A/A genotypes and A carrier were significantly higher in the Helicobacter pylori -infected population, whereas T/T genotypes were predominant among the counterparts (P =0.001). The IL-8 A allele carriers with Helicobacter pylori infection had an increased risk of developing gastritis (P=0.003). Most Grade III gastritis patients (93.7%) were infected with Helicobacter pylori. The frequency of A carrier was much higher (93.3%) than the T/T genotype among Helicobacter pylori -infected chronic active gastritis patients (Grade III), whereas the T/T genotype was observed in 100.0% of Helicobacter pylori-negative Grade III gastritis population. Conclusion: The Helicobacter pylori-infected patients carrying the A allele may increase the risk of gastritis, whereas the T/T genotype is protective. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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