The association between hepatic fibrosis indicators and subclinical carotid atherosclerosis in the population with metabolic dysfunction-associated steatotic liver disease under 50 years old.
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) and subclinical carotid atherosclerosis (SCA) share common roots in systemic inflammation and metabolic dysregulation. Hepatic fibrosis mirrors the intensity of these disturbances; however, its association with SCA in younge...
| Published in: | Nutrition & Metabolism Vol. 22; no. 1; pp. 1 - 16 |
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| Main Authors: | , , , |
| Format: | pictorial research tables/charts Journal Article |
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BioMed Central
11/10/2025
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189234928&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189234928 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 11/10/2025 vid: 22 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 189234928 189234928 189234928 10.1186/s12986-025-01039-3 189234928 ppf: 1 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The association between hepatic fibrosis indicators and subclinical carotid atherosclerosis in the population with metabolic dysfunction-associated steatotic liver disease under 50 years old. aug: au: Zhang, Shuai Liang, Hao Liu, Jun Zhu, Ye affil: https://ror.org/04gz17b59 Department of Gastroenterology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, 225001, Yangzhou, China sug: subj: Metabolic Diseases Complications Nonalcoholic Fatty Liver Disease Risk Factors Carotid Artery Diseases Risk Factors Inflammation Age Factors Risk Assessment Human Funding Source Male Female Adult Middle Age Adolescence Young Adult Retrospective Design Record Review Cross Sectional Studies Health Screening Hypertension Diabetes Mellitus Coronary Disease Hospital Information Systems Diagnostic Tests, Routine Physicians Descriptive Statistics Multiple Logistic Regression Spearman's Rank Correlation Coefficient Correlational Studies Mediation Analysis Body Mass Index ROC Curve Carotid Artery Diseases Classification Odds Ratio Confidence Intervals Adult: 19-44 years Middle Aged: 45-64 years Adolescent: 13-18 years Male Female ab: Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) and subclinical carotid atherosclerosis (SCA) share common roots in systemic inflammation and metabolic dysregulation. Hepatic fibrosis mirrors the intensity of these disturbances; however, its association with SCA in younger adults remains unclear. Methods: A total of 14 567 MASLD patients were enrolled from the health examination center of Northern Jiangsu People's Hospital. Participant stratification into SCA and non-SCA groups was based on carotid ultrasound findings. Variable selection was performed using Least Absolute Shrinkage and Selection Operator (LASSO) regression. The associations between the selected indicators and SCA risk were subsequently evaluated through multivariate logistic regression, restricted cubic spline (RCS) analysis, subgroup analysis, receiver operating characteristic (ROC) curves, and mediation analysis. Results: Both LASSO and multivariate logistic regression analyses demonstrated that elevated NAFLD Fibrosis Score (NFS) and Fibrosis-4 (FIB-4) levels were positively correlated with the prevalence of SCA in patients with MASLD (P for trend < 0.001). Mediation analysis indicated that the Red-cell Distribution Width-to-Albumin Ratio (RAR) significantly mediated this association, with the mediated proportion ranging from 28.6% to 44.6% (P < 0·05). Subgroup analysis identified a significant interaction between age and the association of both fibrosis scores with SCA (P for interaction < 0.05). Subsequently, RCS analysis demonstrated significant positive non-linear associations between NFS/FIB-4 and SCA risk specifically in patients aged under 50 years (P for non-linear < 0.001). The area under the ROC curve (AUC) indicated that both scores had fair predictive value for SCA in this younger subgroup. Conclusion: This study confirms that elevated NFS and FIB-4 levels are significantly associated with an increased risk of SCA in MASLD patients, demonstrating a distinct non-linear relationship and fair predictive value, particularly in individuals under 50 years of age. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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