Association between serum uric acid to creatinine ratio with metabolic profile in subjects with non-alcoholic fatty liver disease (NAFLD).
Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition strongly linked with metabolic syndrome components. The serum uric acid to creatinine (SUA/Cr) ratio has recently emerged as a potential biomarker of metabolic dysfunction. However, its clinical relevance in...
| Publicado en: | BMC Endocrine Disorders Vol. 25; no. 1; pp. 1 - 11 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
BioMed Central
11/13/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189253053&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189253053 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14726823 1CHL jtl: BMC Endocrine Disorders issn: 14726823 maglogo: N pubinfo: dt: 11/13/2025 vid: 25 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 189253053 189253053 189253053 10.1186/s12902-025-02074-0 189253053 ppf: 1 ppct: 10 formats: tig: atl: Association between serum uric acid to creatinine ratio with metabolic profile in subjects with non-alcoholic fatty liver disease (NAFLD). aug: au: El-Sehrawy, Amr Ali Mohamed Abdelgawwad Alshkarchy, Samer Saleem Kareem, Ali Kamil Maashi, Marwah Suliman Al-Khafaji, Zahraa Abbas Hjazi, Ahmed Hsu, Chou-Yi Kadhum, Wesam R. Jafarzadeh, Faria affil: https://ror.org/01k8vtd75 Department of Internal Medicine, Diabetes, Endocrinology and Metabolism, Mansoura University, Mansoura, Egypt sug: subj: Nonalcoholic Fatty Liver Disease Diagnosis Nonalcoholic Fatty Liver Disease Blood Uric Acid Blood Creatinine Blood Metabolic Syndrome X Risk Factors Risk Assessment Human Funding Source Adult Cross Sectional Studies One-Way Analysis of Variance Chi Square Test Analysis of Variance Liver Physiology Enzymes Blood Biological Markers Anthropometry Cholesterol Blood Questionnaires Hyperlipidemia Obesity Lipoproteins, LDL Blood Alanine Aminotransferase Blood Liver Injuries Waist Circumference Waist-Hip Ratio Adult: 19-44 years ab: Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver condition strongly linked with metabolic syndrome components. The serum uric acid to creatinine (SUA/Cr) ratio has recently emerged as a potential biomarker of metabolic dysfunction. However, its clinical relevance in individuals with NAFLD remains underexplored. The objectives of the current research was to investigate the association between the SUA/Cr ratio and metabolic risk factors in adults diagnosed with NAFLD. Methods: This cross-sectional study included 226 adults with ultrasonography-confirmed NAFLD (grades 1 and 2). Participants were categorized into tertiles based on their SUA/Cr ratio. Anthropometric indices, biochemical parameters (lipid profile, liver enzymes, glucose), and lifestyle factors were assessed. Differences across SUA/Cr tertiles were analyzed using ANOVA and general linear models adjusted for confounders. Results: Higher SUA/Cr tertiles were associated with significantly elevated total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels (p = 0.011 and p < 0.001, respectively), and higher alanine aminotransferase (ALT) (p = 0.010), indicating hepatic injury. Central obesity indices (waist circumference and waist-to-hip ratio) increased significantly across tertiles (p = 0.023 and p = 0.025, respectively), although BMI did not. SUA/Cr was not significantly associated with fasting blood glucose or triglycerides. These findings suggest a strong association between elevated SUA/Cr and an unfavorable metabolic and hepatic profile in NAFLD patients. Conclusion: The SUA/Cr ratio is a simple, non-invasive biomarker associated with dyslipidemia, liver enzyme elevation, and central obesity in NAFLD individuals. It may serve as a practical tool for early risk stratification and metabolic monitoring in this high-risk population. Further longitudinal studies are warranted to validate its role in NAFLD progression. Clinical trial number: Not applicable. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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