The effect of postbiotics supplementation on obesity and metabolic health: a systematic review and meta-analysis of randomized control trials.
Background: The prevalence of metabolic disorders such as obesity, type 2 diabetes, and dyslipidemia has increased globally. Postbiotics as non-viable microbial products or metabolites, have recently emerged as potential modulators of metabolic health due to their anti-inflammatory and insulin-sensi...
| Publicado en: | Nutrition & Metabolism Vol. 22; no. 1; pp. 1 - 16 |
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| Autores principales: | , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
BioMed Central
11/13/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189290830&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189290830 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 11/13/2025 vid: 22 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 189290830 189290830 189290830 10.1186/s12986-025-01037-5 189290830 ppf: 1 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The effect of postbiotics supplementation on obesity and metabolic health: a systematic review and meta-analysis of randomized control trials. aug: au: Li, Shuwen Sohouli, Mohammad Hassan Li, Zeli affil: https://ror.org/03qb7bg95 Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan Traditional Chinese Medicine Hospital, 523000, Dongguan, China sug: subj: Probiotics Therapeutic Use Dietary Supplementation Obesity Diet Therapy Metabolic Syndrome X Diet Therapy Treatment Outcomes Human Male Female Adult Middle Age Aged Systematic Review Meta Analysis PubMed Embase Medline Checklists Data Analysis Software Confidence Intervals Descriptive Statistics Sensitivity and Specificity Anthropometry Inflammation Biological Markers Blood Pressure Insulin Blood Triglycerides Blood Waist Circumference C-Reactive Protein Blood Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background: The prevalence of metabolic disorders such as obesity, type 2 diabetes, and dyslipidemia has increased globally. Postbiotics as non-viable microbial products or metabolites, have recently emerged as potential modulators of metabolic health due to their anti-inflammatory and insulin-sensitizing properties. In order to obtain a better viewpoint from them, this study aimed to comprehensively investigate the effects of postbiotics on metabolic health. Methods: This systematic review and meta-analysis, adhering to PRISMA 2020 guidelines, synthesized data from 25 RCTs assessing the effects of postbiotic supplementation on metabolic parameters. Databases including PubMed, Embase, Web of Science, and Scopus were searched up to June 2025. Outcomes included glycemic indices, anthropometric measures, lipid profiles, inflammatory markers, and blood pressure. Results: Postbiotic supplementation significantly reduced serum insulin levels (WMD: − 2.76 µU/mL), triglycerides (TG) (–8.46 mg/dL), waist circumference (WC) (–1.47 cm), and C-reactive protein (CRP) (–0.99 mg/L). However, changes in fasting blood glucose (FBG), homeostatic model assessment for insulin resistance (HOMA-IR), HbA1c, other profile lipids, blood pressure as well as weight and body mass index (BMI) were not statistically significant. Subgroup analyses revealed more pronounced benefits in younger participants, bacterial-based formulations, and interventions longer than 8 weeks. Risk of bias was low to moderate, and no major publication bias was detected. Conclusion: Postbiotic supplementation demonstrates modest but clinically relevant benefits on insulin sensitivity, central adiposity, TG, and systemic inflammation. These effects suggest a promising adjunctive role for postbiotics in metabolic health interventions, though further trials with standardized formulations and longer durations are warranted. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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