Effect of Two Different ART Regimens on AIDS Patients With Lymphoma.
Objective: To explore the impact of two different ART regimens on AIDS patients with lymphoma. Methods: A retrospective study was carried out involving 60 patients diagnosed with AIDS and lymphoma and treated in our hospital during the period from June 2022 to December 2023. All patients underwent D...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 2025; pp. 1 - 10 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
9/24/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189330130&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189330130 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: 9/24/2025 vid: 2025 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 189330130 189330130 189330130 10.1155/jcpt/6644473 189330130 ppf: 1 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Effect of Two Different ART Regimens on AIDS Patients With Lymphoma. aug: au: Ruan, Guangjing Su, Qisi Xie, Zhiman He, Huawei Lu, Yuming Liu, Ningmei Ni, Dandan He, Bin Mircea-Catalin, Fortofoiu affil: Department of Infection,, The Fourth People's Hospital of Nanning,, Nanning, 530021,, Guangxi, China, nn4yy.com sug: subj: Acquired Immunodeficiency Syndrome Drug Therapy Anti-Retroviral Agents Pharmacodynamics Antiretroviral Therapy, Highly Active Treatment Outcomes Lymphoma Comorbidity Drug Therapy, Combination Human Male Female Adult Middle Age AIDS Patients Retrospective Design Record Review Hospitals Chemotherapy, Cancer HIV Integrase Inhibitors Anti-HIV Agents Lamivudine Pharmacodynamics Efavirenz Pharmacodynamics Liver Function Tests Bilirubin Blood Alanine Aminotransferase Blood Aspartate Aminotransferase Blood Albumins Blood Prothrombin Time Creatinine Blood Viral Load Prospective Studies Polymerase Chain Reaction Flow Cytometry Enzyme-Linked Immunosorbent Assay Hemoglobins Analysis of Variance Post Hoc Analysis Cancer Patients Adverse Drug Event Nausea and Vomiting Leukopenia Hepatotoxicity Hyperlipidemia Data Analysis Software Antifungal Agents Therapeutic Use Cryptococcus Drug Effects Fluconazole Therapeutic Use Voriconazole Therapeutic Use Funding Source Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Objective: To explore the impact of two different ART regimens on AIDS patients with lymphoma. Methods: A retrospective study was carried out involving 60 patients diagnosed with AIDS and lymphoma and treated in our hospital during the period from June 2022 to December 2023. All patients underwent DA‐EPOCH chemotherapy. According to the differences in ART treatment regimens, patients receiving the DTG + lamivudine (3TC) regimen will be categorized into the DTG + 3TC group, and patients receiving the TDF + 3TC + efavirenz (EFV) regimen will be classified into the TDF + 3TC + EFV group, with 30 cases in each group. The HIV viral load was compared between the two groups pretreatment and posttreatment (at 12, 24, and 26 weeks). The immunological indices (CD4+ and CD8+), liver function indices (serum total bilirubin [TBIL], alanine transaminase [ALT], aspartate transaminase [AST], serum albumin [ALB], and prothrombin time [PT]), and blood creatinine (Scr) levels of the two groups were compared before and after treatment (at 36 weeks). The occurrence of adverse reactions was documented. Results: After 12, 24, and 36 weeks of treatment, the HIV viral load in the DTG + 3TC group was consistently lower than that in the EFV + TDF + 3TC group (p < 0.05). At week 36 posttreatment, compared with the EFV + TDF + 3TC group, the DTG + 3TC group showed higher CD4+ counts and lower CD8+ counts (p < 0.05). Following treatment at week 36, levels of AST, ALT, TBiL, and PT were elevated in both groups but lower in the DTG + 3TC group (p < 0.05). The levels of ALB in both groups were decreased, but the DTG + 3TC group was significantly higher (p < 0.05). Additionally, at week 36 posttreatment, Scr levels were significantly better in the DTG + 3TC group compared to the EFV + TDF + 3TC group (p < 0.05). The incidence of adverse reactions in the DTG + 3TC group and EFV + TDF + 3TC group differed significantly, with rates of 13.33% and 23.33%, respectively (p > 0.05). Conclusion: There is no difference in the safety of DTG + 3TC in the treatment of AIDS patients with ARL compared with TDF +3TC + EFV. However, the combination of DTG + 3TC simplified regimen is superior to the three‐drug regimen of TDF + 3TC + EFV in reducing viral load and has positive effects on the improvement of liver function and blood creatinine, with no obvious side effects. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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