Thyroid Hormone Resistance Indices and Their Correlations With Insulin Resistance in Chinese Euthyroid Subjects.
Aim: This study aimed to analyze the relationship between sensitivity to thyroid hormones and insulin resistance (IR) in people with different levels of body mass index (BMI). Methods: We included 32,478 euthyroid participants, and they were divided into three groups according to body mass index (BM...
| Published in: | International Journal of Endocrinology Vol. 2025; pp. 1 - 14 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
9/24/2025
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189330784&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189330784 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16878337 8NCM jtl: International Journal of Endocrinology issn: 16878337 maglogo: N pubinfo: dt: 9/24/2025 vid: 2025 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 189330784 189330784 189330784 10.1155/ije/5397686 189330784 ppf: 1 ppct: 13 formats: tig: atl: Thyroid Hormone Resistance Indices and Their Correlations With Insulin Resistance in Chinese Euthyroid Subjects. aug: au: Cui, Ruixiang Li, GuiHua Wei, Ying Liu, Jia Wang, Ying Leng, Song Wang, Guang Saleem, Suraiya affil: Department of Endocrinology,, Beijing Chao-Yang Hospital,, Capital Medical University,, No. 8 Gongti South Road Chaoyang District, Beijing, 100020,, China, ccmu.edu.cn sug: subj: Metabolic Diseases Risk Factors Thyroid Hormones Insulin Resistance Body Mass Index Risk Assessment Human Male Female Adolescence Adult Middle Age Aged Aged, 80 and Over China Academic Medical Centers Cross Sectional Studies Thyroid Function Tests Blood Glucose Analysis Lipids Blood Uric Acid Blood Glycated Hemoglobin Blood Blood Pressure Triglycerides Analysis of Variance Kruskal-Wallis Test Multiple Linear Regression Multiple Logistic Regression Odds Ratio Confidence Intervals Descriptive Statistics Data Analysis Software Funding Source Glucose Metabolism Disorders Risk Factors Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Aim: This study aimed to analyze the relationship between sensitivity to thyroid hormones and insulin resistance (IR) in people with different levels of body mass index (BMI). Methods: We included 32,478 euthyroid participants, and they were divided into three groups according to body mass index (BMI): normal weight (n = 20,200), overweight (n = 10,178), and obesity (n = 2100). We used the Thyroid Feedback Quantile‐based Index (TFQI), the TSH index (TSHI), and the Thyrotroph T4 Resistance Index (TT4RI) to represent thyroid hormones sensitivity and used Triglyceride‐Glucose (TyG) Index, the Atherogenic Index of Plasma (AIP), and The Metabolic Score for Insulin Resistance (METS‐IR) to represent IR. Results: In the BMI < 25 kg/m2 group, linear regression showed that TFQI, TSHI, and TT4RI were all positively correlated with TyG (β = 0.096, 0.089, and 0.089, respectively, all p < 0.001). Logistic regression showed that the odds ratios (ORs) for having high TyG in the highest quartiles of the TFQI, TSHI, and TT4RI were 1.430, 1.537, and 1.518, respectively (all p < 0.001), compared with the lowest quartiles of the TFQI, TSHI, and TT4RI. In the 25 ≤ BMI < 29.9 kg/m2 group, TFQI, TSHI, and TT4RI were positively associated with TyG (β = 0.071, 0.067, and 0.066, respectively, all p < 0.001) according to linear regression. The ORs for having high TyG in the highest quartiles of the TFQI, TSHI, and TT4RI were 1.269, 1.363, and 1.353, respectively (all p < 0.001) by logistic regression. In the BMI ≥ 30 kg/m2 group, positive correlations were found between the three thyroid indices and TyG (βTFQI = 0.097, βTSHI = 0.084, βTT4RI = 0.083, all p < 0.01) by linear regression. The ORs for having high TyG in the highest quartiles of the TFQI, TSHI, and TT4RI were 1.298 (p = 0.101), 1.454 (p = 0.05), and 1.455 (p = 0.05), respectively. Conclusions: Reduced sensitivity to thyroid hormones was associated with high levels of IR in euthyroid adults of normal weight and overweight. In obese patients, no significant correlation was found between sensitivity to thyroid hormones and IR. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|