Brain activity during cognitive-motor tasks in older adults with cognitive frailty: a fNIRS study.
Background: Cognitive frailty has recently drawn increasing attention in the context of elderly healthcare. While structural brain alterations in older adults with cognitive frailty have been previously explored, functional brain changes particularly during cognitive-motor tasks remain poorly unders...
| Publicado en: | Frontiers in Aging Neuroscience pp. 1 - 14 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189515487&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189515487 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 2025 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 189515487 189515487 189515487 10.3389/fnagi.2025.1682050 189515487 ppf: 1 ppct: 13 formats: tig: atl: Brain activity during cognitive-motor tasks in older adults with cognitive frailty: a fNIRS study. aug: au: Wang, Yin-Hsiang Yang, Yea-Ru Yeh, Nai-Chen Li, Pei-Yun Wang, Ray-Yau affil: Department of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University, Taipei, Taiwan sug: subj: Brain Physiology Cognition Psychomotor Performance Frailty Syndrome Task Performance and Analysis Human Cross Sectional Studies Spectroscopy, Near-Infrared Pearson's Correlation Coefficient Spearman's Rank Correlation Coefficient Descriptive Statistics Executive Function Aged Male Female Data Analysis Software Scales T-Tests Mann-Whitney U Test Chi Square Test Post Hoc Analysis Funding Source Aged: 65+ years Male Female ab: Background: Cognitive frailty has recently drawn increasing attention in the context of elderly healthcare. While structural brain alterations in older adults with cognitive frailty have been previously explored, functional brain changes particularly during cognitive-motor tasks remain poorly understood. This study aimed to investigate functional brain activity during such tasks and its relationships with task performance to deepen understanding toward cognitive frailty. Methods: This cross-sectional study included cognitive frail and healthy older adults. Brain activity of bilateral prefrontal, supplementary motor area, and premotor cortex during two differently challenging cognitive-motor tasks and usual walking was measured by functional near-infrared spectroscopy. Cognitive-motor task performance, usual walking speed, physical performance, and executive function were also measured. Generalized estimating equation was used to analyze between tasks and populations. Pearson and Spearman's correlation were used to examine relationships between task performance and brain activity. Results: Older adults with cognitive frailty activated all brain regions more during both cognitive-motor tasks than usual walking (p < 0.05) as healthy control. However, neither group showed increased brain activation during the difficult task compared to the easier (p > 0.05), despite significant task performance decline (p < 0.05). In cognitive frail older adults, activity of bilateral supplementary motor area and left premotor cortex correlated negatively with performance on the difficult task (p < 0.05). Reduced performance in executive and physical functions were also noted in older adults with cognitive frailty (p < 0.05). Conclusion: This study explored possible functional brain alterations of older adults with cognitive frailty, including neural reserve, capacity limitations, and neural inefficiency. The findings possibly contribute to identification of cognitive frailty, and intervention modulating such brain alterations is warranted in future studies. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|