"First, Trust Needs to Develop": Hematologists' Perspectives on Factors Influencing Black Persons' Participation in Clinical Trials.
Background: Cancer clinical trials are crucial for treatment standards and innovation but lack racial-ethnic diversity. Understanding physician perspectives on recruiting participants is critical due to their role in decision-making about trial candidacy and enrollment. Methods: From August 2021 to...
| Publicado en: | Journal of Racial & Ethnic Health Disparities Vol. 12; no. 6; pp. 4111 - 4125 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189534272&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189534272 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 21973792 GQHQ jtl: Journal of Racial & Ethnic Health Disparities issn: 21973792 maglogo: N pubinfo: dt: Dec2025 vid: 12 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 189534272 180323719 189534272 189534272 10.1007/s40615-024-02205-8 189534272 ppf: 4111 ppct: 14 formats: tig: atl: "First, Trust Needs to Develop": Hematologists' Perspectives on Factors Influencing Black Persons' Participation in Clinical Trials. aug: au: Grant, Shakira J. Jean-Baptiste, Milenka Mills, Jiona A. Mihas, Paul affil: https://ror.org/0130frc33 Division of Hematology, The University of North Carolina at Chapel Hill, Houpt Building, Campus Box 7305, 170 Manning Drive, 27514, Chapel Hill, NC, USA sug: subj: Multiple Myeloma African Americans Psychosocial Factors Cancer Patients Psychosocial Factors Patient Participation Clinical Trials Physician Attitudes Evaluation Research Subject Recruitment Human Descriptive Research Qualitative Studies Physicians Psychosocial Factors Funding Source Semi-Structured Interview Medical Mistrust Physician-Patient Relations Communication Audiorecording Cultural Values Systemic Racism North Carolina Adult Middle Age Male Female Purposive Sample Interview Guides Data Analysis Software Descriptive Statistics Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Cancer clinical trials are crucial for treatment standards and innovation but lack racial-ethnic diversity. Understanding physician perspectives on recruiting participants is critical due to their role in decision-making about trial candidacy and enrollment. Methods: From August 2021 to January 2022 we recruited 13 Academic hematologists experienced with treating blood cancers and enrolling clinical trial participants. Each hematologist participated in a 60-75-minute semistructured interview and completed a sociodemographic survey. Using the National Institute on Minority Health and Health Disparities multilevel model as a framework, we characterized hematologists' perceived barriers to clinical trial participation among Black persons. ATLAS.ti v9 and later v 23.2.1 was used for project management and to facilitate data analysis using the Sort and Sift, Think and Shift approach (ResearchTalk Inc). Results: All hematologists were White, with 70% being male. Three factors influenced their perspectives on enrolling Black individuals in clinical trials: individual attitudes and beliefs, such as perceptions that Black or socioeconomically disadvantaged persons will be less willing or less compliant with the requirements for trial participation and follow-up. The need to build trusting relationships between themselves and patients prior to discussing clinical trials and the prevailing legacy of medical mistrust among the Black community. Trust was found to be the underlying factor in determining communication between hematologists and Black persons about clinical trials across all three levels. Conclusion: This study highlights how hematologists' attitudes, beliefs, biases, and views on trust in patient relationships influence their communication with Black individuals about clinical trials. It emphasizes the need for further research to develop interventions that address the lack of racial and ethnic diversity in trials. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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