Fecal Carriage of Multidrug‐Resistant Staphylococcus aureus in Hypertensive Patients at the Douala Laquintinie Hospital: Prevalence and Resistance Patterns.
Patients with hypertension may be more susceptible to acquiring Staphylococcus aureus (S. aureus) infections, according to some studies. Hypertension and certain antihypertensive drugs predispose to multidrug‐resistant bacteria. The present study, carried out at the Laquintinie Hospital in Douala, i...
| Publicado en: | BioMed Research International Vol. 2025; pp. 1 - 14 |
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| Autores principales: | , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
11/26/2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189588335&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189588335 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 11/26/2025 vid: 2025 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 189588335 189588335 189588335 10.1155/bmri/8076503 189588335 ppf: 1 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Fecal Carriage of Multidrug‐Resistant Staphylococcus aureus in Hypertensive Patients at the Douala Laquintinie Hospital: Prevalence and Resistance Patterns. aug: au: Tsobeng, Ornella Djiolieu Mbaveng, Armelle T. Kengne, Michael F. Dadjo, Ballue S. T. Kuete, Victor Banerjee, Baisakhi affil: Department of Biochemistry, , Faculty of Science, , Université de Dschang, , Dschang, Cameroon, univ-dschang.org sug: subj: Drug Resistance, Microbial Evaluation Drug Resistance, Multiple Evaluation Staphylococcal Infections Epidemiology Staphylococcus Aureus Drug Effects Prevalence Evaluation Hypertension Drug Therapy Antihypertensive Agents Therapeutic Use Feces Carrier State Hospitals Cameroon Human Cameroon Male Female Cross Sectional Studies Comparative Studies Descriptive Statistics Microbial Culture and Sensitivity Tests Oxacillin Drug Resistance Trimethoprim-Sulfamethoxazole Combination Blood Pressure Chi Square Test Logistic Regression Odds Ratio Confidence Intervals Data Analysis Software Male Female ab: Patients with hypertension may be more susceptible to acquiring Staphylococcus aureus (S. aureus) infections, according to some studies. Hypertension and certain antihypertensive drugs predispose to multidrug‐resistant bacteria. The present study, carried out at the Laquintinie Hospital in Douala, is aimed at determining the antibiotic‐resistant profile of fecal carriage S. aureus in hypertensive patients and their association with hypertension. This was a cross‐sectional study that was carried out from June 2022 to June 2023. Five hundred and eighteen (518) stool samples were collected, from which the isolation of S. aureus was made using mannitol salt agar. Mannitol fermentation, catalase, and coagulase tests were used for species identification. The Kirby–Bauer disc diffusion method was used for the antibiotic susceptibility assay. Our study revealed that the frequency of fecal carriage of S. aureus was significantly higher in hypertensive participants (65.15%, n = 43) compared to nonhypertensive participants (34.85%, n = 23). The frequency of fecal carriage of methicillin‐resistant S. aureus (MRSA) was significantly higher in participants with hypertension compared to nonhypertensive participants (88.37% vs. 47.83%, p ~ 0.001). The antibiotic susceptibility test revealed that the resistance of S. aureus to fusidic acid, cotrimoxazole, and oxacillin was significantly higher in hypertensive than in nonhypertensive patients. There was a significant association between hypertension and S. aureus resistance to oxacillin (OR = 8.29, p ~ 0.001) and trimethoprim–sulfamethoxazole (OR = 6.07, p = 0.001). In addition, S. aureus isolates showed high resistance rates in treated hypertensive participants compared to untreated hypertensive participants. This study reveals that S. aureus exhibits high resistance to many of the clinically used antimicrobials. The need for appropriate antibiotic use to halt, or at least limit, the spread of resistance is suggested in the care of hypertensive patients with enteric infection caused by S. aureus. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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