Subcortical functional connectivity alterations in first-episode medication-naïve adolescents with major depressive disorder.
Major depressive disorder (MDD) demonstrates significant alterations in intrinsic functional connectivity (FC) of the subcortical networks (SCN). However, the neurobiological mechanisms underlying these changes in adolescents with MDD and their association with stressors and sleep disturbances remai...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 34; no. 11; pp. 3535 - 3548 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189593508&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189593508 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Nov2025 vid: 34 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 189593508 185707942 189593508 189593508 10.1007/s00787-025-02774-x 189593508 ppf: 3535 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Subcortical functional connectivity alterations in first-episode medication-naïve adolescents with major depressive disorder. aug: au: Sun, Lei Zhou, Zilin Feng, Ruohan Gao, Yingxue Bao, Weijie He, Hong Li, Hongwei Hu, Xinyue Li, Hailong Zhang, Lianqing Huang, Guoping Huang, Xiaoqi affil: https://ror.org/011ashp19 Department of Radiology, Huaxi MR Research Center (HMRRC), Institution of Radiology and Medical Imaging, West China Hospital, Sichuan University, Chengdu, China sug: subj: Depression Physiopathology Cerebral Cortex Radiography Functional Connectivity Evaluation Sleep Disorders Diagnosis Life Change Events Evaluation Family Relations Evaluation Human Male Female Adolescence China Correlational Studies Comparative Studies Descriptive Statistics Data Analysis Software Questionnaires Psychological Tests Magnetic Resonance Imaging Disease Attributes Amygdala Radiography Thalamus Radiography Hippocampus Radiography Basal Ganglia Radiography Stress Disorders, Post-Traumatic Diagnosis Depression Psychosocial Factors Family Characteristics Funding Source Adolescent: 13-18 years Male Female ab: Major depressive disorder (MDD) demonstrates significant alterations in intrinsic functional connectivity (FC) of the subcortical networks (SCN). However, the neurobiological mechanisms underlying these changes in adolescents with MDD and their association with stressors and sleep disturbances remain poorly understood. Using seed-based functional connectivity analysis, we investigated changes in intrinsic connectivity of the SCN in 83 first-episode medication-naïve adolescents with MDD (aMDD) and 59 healthy controls (HC). We then examined the correlation between the SCN connectivity alterations with sleep disturbances and stress factors, measured by the Pittsburgh Sleep Quality Index (PSQI), the Adolescent Life Events Checklist (ASLEC), and the Family Environment Scale-Chinese Version (FES-CV). Compared with HC, aMDD patients showed decreased connectivity between multiple subcortical regions (amygdala, hippocampus, nucleus accumbens (NAc), and thalamus) and cortical regions of the limbic (orbital frontal cortex, inferior temporal gyrus, temporal pole), visual (middle occipital gyrus) and sensorimotor (precentral gyrus) networks. Moreover, we observed that reduced amygdala- and NAc-based FC was correlated with more stress from life events, while reduced thalamus-based FC was associated with more severe sleep disturbances. Our study was the first to comprehensively investigate the SCN-based FC alterations in adolescents with MDD. We revealed disruptions in connectivity between the SCN and cortical networks in aMDD, and further identified potential environmental mechanisms associated with these SCN-based dysconnectivity patterns. These findings underscore critical role of the SCN in the neurobiological mechanisms of aMDD and suggest potential targets for developing novel treatment strategies for adolescents with MDD. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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