Estimated Amounts of β-Carotene, Vitamin B6, Riboflavin and Niacin in the Daily Diet of Older Subjects Associate Negatively with ADP-Induced Aggregation of Blood Platelets Independently of Cardiovascular Risk Factors.
Background/Objectives: Platelet-dependent thrombotic risk increases with age. Little is known, however, about the potential effect of vitamins on platelet reactivity in older subjects. Methods: Therefore, in the present study we examined the dependencies of whole blood platelet aggregability (in res...
| Publicado en: | Nutrients Vol. 17; no. 21; pp. 3461 - 3488 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
MDPI
Nov2025
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189606639&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189606639 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Nov2025 vid: 17 iid: 21 pid: 97109 pub: MDPI artinfo: ui: 189606639 189606639 189606639 10.3390/nu17213461 189606639 ppf: 3461 ppct: 27 formats: tig: atl: Estimated Amounts of β-Carotene, Vitamin B6, Riboflavin and Niacin in the Daily Diet of Older Subjects Associate Negatively with ADP-Induced Aggregation of Blood Platelets Independently of Cardiovascular Risk Factors. aug: au: Karolczak, Kamil Guligowska, Agnieszka Sołtysik, Bartłomiej K. Kostanek, Joanna Kostka, Tomasz Watala, Cezary affil: Department of Haemostatic Disorders, Medical University of Lodz, ul. Mazowiecka 6/8, 92-215 Lodz, Poland sug: subj: beta Carotene Administration and Dosage Pyridoxine Administration and Dosage Riboflavin Administration and Dosage Niacin Administration and Dosage Platelet Aggregation Drug Effects Blood Platelets Drug Effects Adenosine Diphosphate Adverse Effects Cardiovascular Risk Factors Diet Treatment Outcomes Funding Source Poland Human Male Female Middle Age Aged Arachidonic Acids Collagen Vitamins Unpaired T-Tests Mann-Whitney U Test Spearman's Rank Correlation Coefficient Pearson's Correlation Coefficient Multiple Regression Chi Square Test Fisher's Exact Test Data Analysis Software Descriptive Statistics Questionnaires Interviews Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Background/Objectives: Platelet-dependent thrombotic risk increases with age. Little is known, however, about the potential effect of vitamins on platelet reactivity in older subjects. Methods: Therefore, in the present study we examined the dependencies of whole blood platelet aggregability (in response to arachidonic acid (AA), collagen (COL) or adenosinediphosphate (ADP), using impedance aggregometry) in older men and women (60–65 yr, n = 246) on the intakes of vitamins (vitamins A, E, C, B6, B12 and D, niacin, thiamine, riboflavin, retinol, β-carotene and folates) with a typical daily diet (vitamin contents estimated using Dieta 5.0 software). Results: Overall, significant negative bootstrap-boosted partial correlation coefficients, adjusted for selected cardiovascular risk factors, were revealed for AA and β-carotene, and ADP and β-carotene, riboflavin, vitamin B6 and niacin. These findings were further validated by the outcomes of the bootstrap-boosted canonical analysis, confirming the relationships revealed for ADP, and to a lesser extent for AA. COL-dependent platelet aggregation appeared to not be associated with the amount of vitamins in the subjects' daily diet. Conclusions: Hence, we conclude that the intake of vitamins in the daily diet of older subjects is negatively associated with platelet aggregability in an agonist- and vitamin-specific manner. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|