The clinical value of FAPI PET/CT in delineating target volumes for nasopharyngeal carcinoma.
Purpose: To evaluate the efficacy of 18F-AIF-NOTA-FAPI-04 PET/CT in improving the accuracy of target volume delineation in nasopharyngeal carcinoma (NPC). Methods: Automatic delineation of the primary tumor target volume was conducted for 21 newly diagnosed NPC patients using 18F-AIF-NOTA-FAPI-04 PE...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 53; no. 1; pp. 105 - 116 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189634233&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189634233 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Dec2025 vid: 53 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 189634233 185518494 10.1007/s00259-025-07347-3 189634233 ppf: 105 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The clinical value of FAPI PET/CT in delineating target volumes for nasopharyngeal carcinoma. aug: au: Xu, Wansu Zou, Yihe Zhang, Yang Lv, Qiyuan Deng, Xia Li, Kejie Zhang, Xuemei Wang, Junhui Yu, Wenliang Xie, Raoying Su, Meng He, Huijuan Zou, Changlin affil: https://ror.org/00rd5t069 Department of Radiation Oncology, Quzhou People's Hospital, The Quzhou Affiliated Hospital of Wenzhou Medical University, RD. Minjiang, Dist. Kecheng, Quzhou, Zhejiang, China sug: ab: Purpose: To evaluate the efficacy of 18F-AIF-NOTA-FAPI-04 PET/CT in improving the accuracy of target volume delineation in nasopharyngeal carcinoma (NPC). Methods: Automatic delineation of the primary tumor target volume was conducted for 21 newly diagnosed NPC patients using 18F-AIF-NOTA-FAPI-04 PET/CT images, which applied a threshold-based segmentation with 5% increments from 20 to 60% of SUVmax. Manual delineation of the primary tumor was performed on MRI images. The study analyzed the gross target volumes (GTV) discrepancies between 18F-AIF-NOTA-FAPI-04 PET/CT and MRI. Furthermore, we compared how the two imaging modalities affected the assessment of the primary tumors' involvement of bone-related structures and soft tissue (mucosa) infiltration. Results: There were variations in the primary tumor target volume across the different imaging methods. There were no significant differences observed between GTV-FAPI 20%, GTV-FAPI 25%, and GTV-FAPI 30% compared to GTV-MRI. Among them, GTV-FAPI 20% showed the closest similarity to GTV-MRI. 18F-AIF-NOTA-FAPI-04 PET/CT was superior to MRI in detecting soft tissue and bone tissue involvement in primary tumors. Conclusions: 18F-AIF-NOTA-FAPI-04 PET/CT enhances precision in delineating GTV for NPC and demonstrates clinical utility in T-staging. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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