Exploring the relationship between prefrontal cortex activation, standing balance, and fatigue in people post-stroke: A fNIRS study.

Background: Balance impairments and fatigue are common after stroke and impact physical therapy assessments and treatments. Reasons are multifactorial and include motor dysfunction and changes to cortical activation poststroke. The prefrontal cortex (PFC) is involved in motor control; yet, limited r...

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Publicado en:NeuroRehabilitation Vol. 57; no. 3; pp. 352 - 363
Autores principales: Kohli, Sarthak, Fitzgibbon-Collins, Laura K., Luan, Siying, Durand, Nathan, Brunton, Laura, Fleet, Jamie, Christie, Anita, Viana, Ricardo, Teasell, Robert, Peters, Sue
Formato: pictorial research tables/charts Journal Article
Publicado: Sage Publications Inc. Nov2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Nov2025
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        atl: Exploring the relationship between prefrontal cortex activation, standing balance, and fatigue in people post-stroke: A fNIRS study.
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          Kohli, Sarthak
          Fitzgibbon-Collins, Laura K.
          Luan, Siying
          Durand, Nathan
          Brunton, Laura
          Fleet, Jamie
          Christie, Anita
          Viana, Ricardo
          Teasell, Robert
          Peters, Sue
        affil: Graduate Program in Health and Rehabilitation Sciences, Faculty of Health Sciences, Western University, London, Ontario, Canada
      sug:
        subj:
          Stroke Physiopathology
          Stroke Rehabilitation
          Prefrontal Cortex Physiology
          Balance, Postural Physiology
          Fatigue Etiology
          Fatigue Psychosocial Factors
          Spectroscopy, Near-Infrared Methods
          Human
          Male
          Female
          Middle Age
          Aged
          Aged, 80 and Over
          Hemiplegia Physiopathology
          Hemiplegia Rehabilitation
          Motor Activity Physiology
          Brain Mapping
          Oxygen Consumption
          Dominance, Cerebral
          Physical Therapy
          Task Performance and Analysis
          Patient Centered Care
          Scales
          Nonexperimental Studies
          Funding Source
          Clinical Assessment Tools
          Middle Aged: 45-64 years
          Aged: 65+ years
          Aged, 80 & over
          Male
          Female
      ab: Background: Balance impairments and fatigue are common after stroke and impact physical therapy assessments and treatments. Reasons are multifactorial and include motor dysfunction and changes to cortical activation poststroke. The prefrontal cortex (PFC) is involved in motor control; yet, limited research has explored cortical activation during common physical therapy balance tasks or the link with fatigue. Objectives: During standing balance tasks, the objective was to determine whether PFC activation levels: (1) change between tasks, (2) are asymmetric, and (3) are associated with fatigue. Methods: Patients with hemiparesis were recruited from an inpatient stroke unit and functional near-infrared spectroscopy was applied bilaterally over the PFC to measure cortical activation during balance tasks. Fatigue was assessed using the Fatigue Severity Scale (FSS). Results: Nine participants were included. PFC activation during semi-tandem stance showed greater amplitude than during double-leg stance, indicating more cortical activation. Bilateral PFC activation was observed during both tasks. Participants with greater fatigue (higher FSS score) showed more activation in the ipsilesional PFC than the contralesional PFC. Conclusion: PFC activation may occur when performing more challenging balance postures, potentially indicating compensatory activation, and may be linked with greater fatigue.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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