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Small Intestinal Bacterial Overgrowth in Children with Short Bowel Syndrome.

Small Intestinal Bacterial Overgrowth (SIBO) is characterized by an abnormal proliferation of bacteria in the small intestine, leading to gastrointestinal symptoms and nutritional deficiencies. Short Bowel Syndrome (SBS), resulting from extensive surgical resection of the small intestine, predispose...

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Published in:Children Vol. 12; no. 11; pp. 1550 - 1569
Main Authors: DeGonza, Hannah, Pham, Thu Anh, Elmaoued, Rasha, Alkhouri, Razan, Castillo, Ricardo Orlando, Dharmaraj, Rajmohan
Format: pictorial review tables/charts Journal Article
Published: MDPI Nov2025
Online Access:View this record in EBSCOhost
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      dt: Nov2025
      vid: 12
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      pid: 97109
      pub: MDPI
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        atl: Small Intestinal Bacterial Overgrowth in Children with Short Bowel Syndrome.
      aug:
        au:
          DeGonza, Hannah
          Pham, Thu Anh
          Elmaoued, Rasha
          Alkhouri, Razan
          Castillo, Ricardo Orlando
          Dharmaraj, Rajmohan
        affil: Division of Gastroenterology, Department of Pediatrics, University of New Mexico, Albuquerque, NM 87131, USA
      sug:
        subj:
          Intestine, Small Microbiology
          Short Bowel Syndrome Complications
          Bacterial Colonization
          Bacterial Infections Risk Factors
          Risk Assessment
          Gut Microbiota Analysis
          Malabsorption Syndromes Risk Factors
          Nutritional Status
          Short Bowel Syndrome Surgery
          Intestine, Small Anatomy and Histology
          Gastrointestinal Motility
          Parenteral Nutrition
          Nutritional Support
          Immunocompetence
          Bloat Symptoms
          Diarrhea Symptoms
          Failure to Thrive
          Acidosis, Lactic
          Breath Tests
          Jejunum Pathology
          Biopsy, Needle
          Rifaximin Therapeutic Use
          Metronidazole Therapeutic Use
          Recurrence Prevention and Control
          Probiotics Therapeutic Use
          Diet
          Glucagon-Like Peptide 2 Therapeutic Use
          Multidisciplinary Care Team
          Bacterial Infections Physiopathology
          Bacterial Infections Symptoms
          Bacterial Infections Diagnosis
          Gastric Acid Physiology
          Bile Acids and Salts Metabolism
          Antiinfective Agents Therapeutic Use
          Mucositis, Gastrointestinal Microbiology
          Micronutrients
          Microbial Culture and Sensitivity Tests
          Feces Analysis
          Bacterial Infections Drug Therapy
          Child
          Child: 6-12 years
      ab: Small Intestinal Bacterial Overgrowth (SIBO) is characterized by an abnormal proliferation of bacteria in the small intestine, leading to gastrointestinal symptoms and nutritional deficiencies. Short Bowel Syndrome (SBS), resulting from extensive surgical resection of the small intestine, predisposes children to SIBO due to anatomical disruptions, motility dysfunction, parenteral nutrition dependence, and immune dysregulation. Clinical manifestations of SIBO in SBS include bloating, diarrhea, malabsorption, and failure to thrive, with severe cases leading to complications such as D-lactic acidosis. Diagnosis remains challenging, with breath testing being the most commonly used method despite limitations in accuracy, especially in SBS patients. Jejunal aspiration, the gold standard, presents limitations due to contamination risks, potential for sampling error, and a relatively low diagnostic yield. Management involves antibiotics like rifaximin and metronidazole, alongside strategies to address anatomical dysfunction, optimize nutrition, and prevent recurrence. Adjunctive therapies, including probiotics and dietary modifications, show promise but require further validation in children. Emerging treatments, such as glucagon-like peptide-2 (GLP-2) analogs, may enhance mucosal integrity and reduce SIBO risk. Given the chronic and recurrent nature of SIBO in SBS, a multidisciplinary approach is essential, integrating gastroenterological, surgical, and nutritional care to effectively manage the condition. Future research should focus on improving diagnostic methods, refining treatment protocols, and exploring targeted therapies to enhance outcomes and quality of life for affected children.
      pubtype: Academic Journal
      doctype:
        pictorial
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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