Effects of branched-chain amino acid-rich nutritional supplements combined with resistance training on body composition and body function in older patients with sarcopenia.
• This meta-analysis indicates that supplementation with branched-chain amino acid–enriched nutritional products in combination with resistance training significantly increases skeletal muscle mass index (SMI) in older adults with sarcopenia, whereas no improvements were observed in physical functio...
| Publicado en: | Archives of Gerontology & Geriatrics Vol. 141 |
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| Autores principales: | , , , , , , |
| Formato: | research systematic review Journal Article |
| Publicado: |
Elsevier B.V.
Feb2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189667513&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189667513 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01674943 3HX jtl: Archives of Gerontology & Geriatrics issn: 01674943 maglogo: N pubinfo: dt: Feb2026 vid: 141 pid: 1004 pub: Elsevier B.V. artinfo: ui: 189667513 189667513 189667513 10.1016/j.archger.2025.106063 189667513 ppct: 1 formats: tig: atl: Effects of branched-chain amino acid-rich nutritional supplements combined with resistance training on body composition and body function in older patients with sarcopenia. aug: au: Li, Haoran Zhang, Runfa Ma, Yongye He, Jiaxin Li, Guoxing Sun, Jian DuanyingLi affil: School of Athletic Training, Guangzhou Sport University, Guangzhou, Guangdong, China sug: subj: Amino Acids, Branched-Chain Therapeutic Use Dietary Supplements Therapeutic Use Resistance Training Body Composition Evaluation Geriatric Functional Assessment Sarcopenia Therapy Treatment Outcomes Combined Modality Therapy Dietary Supplementation Human Systematic Review Meta Analysis Exploratory Research Muscle, Skeletal Body Mass Index Evaluation Dietary Proteins Food Intake Aged Aged, 80 and Over Data Analysis Software Descriptive Statistics Confidence Intervals Grip Strength Evaluation Standing Evaluation Walking Speed Evaluation Knee Joint Physiology Extension Fat Free Mass Adipose Tissue Aged: 65+ years Aged, 80 & over ab: • This meta-analysis indicates that supplementation with branched-chain amino acid–enriched nutritional products in combination with resistance training significantly increases skeletal muscle mass index (SMI) in older adults with sarcopenia, whereas no improvements were observed in physical function or other body composition outcomes. • Compared with resistance training alone, BCAA-rich supplementation plus resistance training significantly improved skeletal muscle index (SMI) in older adults with sarcopenia, but showed no significant improvement in physical function or other body composition outcomes. • For older adults with sarcopenia, the clinical value of SMI improvement without functional gains remains uncertain. • This exploratory study suggests that variations in daily protein intake may influence the independent effects of BCAA; future studies should standardize protein intake to clarify this relationship. Sarcopenia impairs self-care ability in older adults. While branched-chain amino acids (BCAAs)/leucine enhance muscle protein synthesis and resistance training promotes muscle growth, the combined effect on sarcopenia remains unclear. This meta-analysis evaluates whether combining resistance training with BCAA-rich supplements synergistically improves body composition and function in sarcopenic elders. We systematically searched four databases and analyzed outcomes using Stata 18.0. Standardized mean differences (SMDs) were calculated via random-effects models. Twelve randomized trials (n = 459) were included. Only skeletal muscle index significantly improved with combined intervention vs. control (SMD = 0.337, 95 % CI [0.035,0.639], p = 0.029). No significant differences were found in: hand grip strength (SMD = 0.289, p = 0.080), 30-s chair stand (SMD = -0.794, p = 0.169), SPPB (SMD = -0.321, p = 0.124), walking speed (SMD = 0.344, p = 0.283), knee extension strength (SMD = 0.332, p = 0.328), total lean mass (SMD = 0.024, p = 0.908), or fat mass (SMD = -0.036, p = 0.866; all p > 0.05). BCAA supplementation post-resistance training only increased skeletal muscle index in older adults, without improving other functional or body composition outcomes. pubtype: Academic Journal doctype: meta analysis research systematic review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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